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Study identifier: NCT06864104 Synced from ClinicalTrials.gov · August 08, 2026
● Study status: Completed

A Study to Investigate Tonlamarsen for the Treatment of Adults With Uncontrolled Hypertension (KARDINAL)

Condition: Hypertension  ·  Sponsor: Kardigan, Inc.

PhasePhase 2
Planned participants206
Who can joinAll sexes, 18 Years to 80 Years
Healthy volunteersNoCheck eligibility criteria ↓
Where39 locations

Sponsor, CRO or site team? See where this study is running → — listed sites, countries and recruiting context. Everything below is written for patients and caregivers.

About this study

The purpose of this study is to evaluate the blood pressure (BP)-lowering efficacy of tonlamarsen in adult participants who, despite taking 2 or more antihypertensive medications, have not achieved their target blood pressure (BP).

This description comes directly from the study's public registry record.

Talk to the study team

No contact information is available for this study as per the public registry record.

Always discuss trial participation with your own doctor first.

Full eligibility criteria (exactly as the study team wrote them)

Key Inclusion Criteria: * Age 18 to 80, body weight ≥ 50 kg * Has uncontrolled hypertension while receiving between 2 and 5 antihypertensive medications prescribed for hypertension * Has mean office seated systolic blood pressure \> 135 to ≤ 170 mmHg Key Exclusion Criteria: * Has known history of secondary hypertension * Has documented history of poor adherence to antihypertensive medication * Has unstable/underlying known cardiovascular disease * Has abnormal thyroid function with clinical significance

Reproduced word-for-word from the public registry record — the study team can answer questions about it.

Locations (39)

Pinnacle Research GroupAnniston, Alabama, United States
Achieve Clinical Research, LLCBirmingham, Alabama, United States
Elite Clinical StudiesPhoenix, Arizona, United States
Del Sol Research Management, LLCTucson, Arizona, United States
Cardiology and Medicine ClinicLittle Rock, Arkansas, United States
North Coast CardiologyEncinitas, California, United States
Orange County Research CenterLake Forest, California, United States
Clinical Trials ResearchLincoln, California, United States
American Institute of ResearchLos Angeles, California, United States
Homestead Associates in Research, Inc.Homestead, Florida, United States
Jacksonville Center for Clinical ResearchJacksonville, Florida, United States
Suncoast Clinical Research, Inc.New Port Richey, Florida, United States

+ 27 more locations — full list on the registry record.

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