EICHORCondition: Colorectal Cancer · Sponsor: IRCCS San Raffaele
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Colorectal cancer is the first leading cause of cancer death in men and second in women. Its incidence rates also increased by 1%-2% annually in young adults (ages \<55 years). The liver is the most common site of colorectal cancer metastasis, with approximately 25% 50% of patients developing liver metastases during the disease. Maximising resection of liver metastasis using all available techniques remains a key objective and provides the best chance of long-term survival and cure. For unresectable patients, optimal systemic and locoregional chemotherapeutic, biological and radiotherapeutic treatments improve survival, and may convert initially unresectable patients to operability. Computed Tomography is currently the modality of choice for patients staging and restaging for high spatial resolution providing accurate delineation of lesion, vascular structure and relation with surrounding structure. The portal venous phase (approximately 60-70 s after administration of contrast agent) is the most reliable phase for detection of liver metastasis with a detection rate of 85% with lower performance for lesion \<1 cm which are interpreted as too small to characterize. Compared to computed tomography, MRI has superior soft tissue contrast and the possibly of a multiparametric characterization of lesion thanks to the evaluation of diffusivity and the uptake of hepatospecific contrast media, resulting in higher accuracy also for lesion smaller than \< 10 mm. Photon-counting detector…
This description comes directly from the study's public registry record.
Antonio Esposito, MD · 0226436102 · esposito.antonio@hsr.it
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Inclusion Criteria: * adult (\>18 years) * non- biopsy-proven colon/colorectal carcinoma * CT performed on a PCD-CT * MRI with multiparametric protocol and hepatospecific contrast media Exclusion Criteria: * pregnancy and breastfeeding * CT exam performed on a scan different from PCD-CT * absence of multiparametric MRI * MRI with non hepatospecific contrast agent * Absent informed consent signed
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| IRCCS San Raffaele | Milan, Italy | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06753903