EICHORCondition: Oral Cancer · Head and Neck Neoplasms · Sponsor: All India Institute of Medical Sciences, Jodhpur
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A majority of oral cancer patients in India present in the advanced stage hence tend to have poor oncological outcomes. Chemotherapy has been associated with improved oncological outcomes in various cancers but its role in oral cancer is not well defined in curative setting apart from radio sensitization. Attempted trials of neoadjuvant chemotherapy failed to show oncological advantage despite an excellent response rate, in part due to poor patient selection. Patients with a biologically aggressive disease are more likely to benefit, hence we intend to find out the oncological advantage of adding induction chemotherapy to oral squamous cell cancer with advanced nodal disease (N2-N3). Earlier studies suffered from their heterogeneous patient population- all head and neck subsites together and included a spectrum ranging from early- stage operable cases to inoperable cancer. Due to such patient selection, the intended results were never met. The current study is intended to study the role of chemotherapy in curable patients who are most likely to benefit (biologically aggressive and advanced stage of presentation). Objective Primary: To study the 2 year disease free survival by adding induction chemotherapy before surgery in patients of oral cancer with advanced nodal disease as compared to upfront surgery. Secondary: To assess treatment related outcomes between the treatment arms- Response rate; Treatment compliance; treatment related toxicity, postoperative complication…
This description comes directly from the study's public registry record.
Dharma R Poonia, MS DNB · 9958654196 · pooniadr@aiimsjodhpur.edu.in
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| All India Institute of Medical Sciences, Bhubaneshwar | Bhubaneswar, Odisha, India | Not Yet Recruiting |
| All India Institute of Medical Sciences, Jodhpur | Jodhpur, Rajasthan, India | Recruiting |
| All India Institute of Medical Sciences, Bathinda | Bathinda, India | Not Yet Recruiting |
| Shri Mahant Indresh Hospital, Dehradun | Dehradun, India | Not Yet Recruiting |
| King George's Medical University | Lucknow, India | Not Yet Recruiting |
| All India Institute of Medical Sciences, Rishikesh | Rishikesh, India | Not Yet Recruiting |
| Geetanjali Medical College, Udaipur | Udaipur, India | Not Yet Recruiting |
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Source record: clinicaltrials.gov/study/NCT06737822