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Study identifier: NCT06646276 Synced from ClinicalTrials.gov · August 08, 2026
● Study status: Recruiting

A Study to Compare the Efficacy and Safety of BMS-986489 (BMS-986012+ Nivolumab Fixed Dose Combination) in Combination With Carboplatin Plus Etoposide to That of Atezolizumab With Carboplatin Plus Etoposide as First-Line Therapy in Participants With Extensive-Stage Small Cell Lung Cancer (TIGOS).

Condition: Extensive-Stage Small Cell Lung Cancer  ·  Sponsor: Bristol-Myers Squibb

PhasePhase 3
Planned participants530
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNoCheck eligibility criteria ↓
Where183 locations · 26 countries

Interested? Contact the study team ↓

Sponsor, CRO or site team? See where this study is running → — listed sites, countries and recruiting context. Everything below is written for patients and caregivers.

About this study

The Purpose of the Study is to Compare the Efficacy and Safety of BMS-986489 (Anti-fucosyl-GM1+ Nivolumab Fixed Dose Combination) in Combination with Carboplatin plus Etoposide to that of Atezolizumab with Carboplatin plus Etoposide as First-Line Therapy in Participants with Extensive-Stage Small Cell Lung Cancer.

This description comes directly from the study's public registry record.

Talk to the study team

BMS Clinical Trials Contact Center www.BMSClinicalTrials.com  ·  855-907-3286  ·  Clinical.Trials@bms.com

First line of the email MUST contain NCT # and Site #.

There is no obligation to join — the study team can answer your questions about taking part.

Always discuss trial participation with your own doctor first.

Full eligibility criteria (exactly as the study team wrote them)

Inclusion Criteria * Participants must have diagnosis of Extensive-Stage Small Cell Lung Cancer (ES-SCLC). * Participants must be Healthy enough to do their normal activities with little or no help based on the ECOG performance scale. * Participants must have at least one tumor that can be measured using special imaging techniques like a CT scan or MRI at a site other than the brain and nervous system Exclusion Criteria * Participants have already received certain types of treatment for extensive stage small cell lung cancer * Participants have certain health conditions, like spread of small cell lung cancer to the brain that are causing symptoms, certain lung diseases, heart diseases, infections, autoimmune diseases, other cancers, or a type of nerve damage called peripheral sensory neuropathy * Other protocol-defined Inclusion/Exclusion criteria apply.

Reproduced word-for-word from the public registry record — the study team can answer questions about it.

Locations (183)

Southern Cancer Center, PCDaphne, Alabama, United StatesRecruiting
Local Institution - 0283Hot Springs, Arkansas, United StatesCompleted
Florida Cancer Specialists - SouthFort Myers, Florida, United StatesRecruiting
Mid Florida Hematology and Oncology CenterOrange City, Florida, United StatesRecruiting
Florida Cancer Specialists - NorthSt. Petersburg, Florida, United StatesRecruiting
Northwest Georgia Oncology Centers, a Service of Wellstar Cobb HospitalMarietta, Georgia, United StatesRecruiting
Illinois Cancer CarePeoria, Illinois, United StatesRecruiting
Local Institution - 0037Minneapolis, Minnesota, United StatesWithdrawn
University of New Mexico Comprehensive Cancer CenterAlbuquerque, New Mexico, United StatesRecruiting
Duke Cancer InstituteDurham, North Carolina, United StatesRecruiting
Sanford Medical CenterBismarck, North Dakota, United StatesRecruiting
Sanford Fargo Medical CenterFargo, North Dakota, United StatesRecruiting

+ 171 more locations — full list on the registry record.

More studies in these areas

This study lists sites in the areas below. Each link shows other recruiting studies near that city, from the public registry record.

DaphneFort MyersOrange CitySt. Petersburg

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