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Study identifier: NCT06521866 Synced from ClinicalTrials.gov · August 07, 2026
● Study status: Recruiting

Phase II Study of Serplulimab Combined with First-Line Targeted Therapy, Chemotherapy, and Radiation in Advanced Colorectal Cancer

Condition: Advanced Colorectal Carcinoma · Immunotherapy  ·  Sponsor: Fudan University

PhasePhase 2
Planned participants208
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

Sponsor, CRO or site team? See where this study is running → — listed sites, countries and recruiting context. Everything below is written for patients and caregivers.

About this study

Study Title: A Prospective, Randomized, Phase II, Multicenter Clinical Study of Serplulimab Combined with Targeted Therapy, Chemotherapy, and Optional Radiotherapy in Advanced Colorectal Cancer Study Objective: To explore the efficacy and safety of immune checkpoint inhibitor combined with targeted therapy and chemoradiotherapy in locally advanced unresectable or metastatic colorectal cancer. Study Population: Patients with left-sided wild-type, right-sided, or RAS-mutant advanced colorectal cancer who have not received systemic treatment. Study Endpoints: Progression-free survival (PFS), objective response rate (ORR), overall survival (OS), safety, and R0 resection rate. Study Design: Prospective, randomized Phase II clinical study.

This description comes directly from the study's public registry record.

Talk to the study team

Dawei Li, PhD  ·  13774201693  ·  li_dawei@fudan.edu.cn

Always discuss trial participation with your own doctor first.

Locations (10)

Fujian Cancer HospitalFuzhou, Fujian, ChinaNot Yet Recruiting
The First Affiliated Hospital of Xiamen UniversityXiamen, Fujian, ChinaNot Yet Recruiting
Lanzhou Military Region General HospitalLanzhou, Gansu, ChinaNot Yet Recruiting
The First Affiliated Hospital of Zhengzhou UniversityZhengzhou, Henan, ChinaNot Yet Recruiting
Huai'an Second People's HospitalHuaian, Jiangsu, ChinaNot Yet Recruiting
Qianfoshan Hospital of Shandong ProvinceJinan, Shandong, ChinaNot Yet Recruiting
Taian City Central HospitalTaian, Shandong, ChinaNot Yet Recruiting
Fudan University Shanghai Cancer CenterShanghai, Shanghai Municipality, ChinaRecruiting
Yunnan Cancer HospitalKunming, Yunnan, ChinaNot Yet Recruiting
Anyang Cancer HospitalAnyang, ChinaNot Yet Recruiting

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