EICHORCondition: Schizophrenia · Cognitive Impairment · Sponsor: Alto Neuroscience
Interested? Contact the study team ↓
This is a Phase 2, double-blind, placebo-controlled, two-way crossover study to compare the efficacy of ALTO-101T versus placebo in change in electroencephalogram (EEG) cognitive processing markers and measures of cognition. Additional goals are to assess pharmacokinetic (PK), safety, and tolerability of the recently developed ALTO-101T transdermal delivery system (TDS) formulation in a patient population.
This description comes directly from the study's public registry record.
Alto Neuroscience · 650-200-0412 · clinical@altoneuroscience.com
There is no obligation to join — the study team can answer your questions about taking part.
Always discuss trial participation with your own doctor first.
Inclusion Criteria: * Schizophrenia diagnosis for at least one year * Cognitive impairment * Stable doses of 1-2 antipsychotic medication(s) for at least 8 weeks at Visit 2 * Positive and Negative Syndrome Scale (PANSS) score: items P1, P3-P6 ≤ 5 and item P2 and P7 ≤ 4 during screening * Have a body mass index (BMI) ≥ 18.0 and ≤ 37.0 kg/m2 (inclusive) * Willing to comply with all study assessments and procedures Exclusion Criteria: * Evidence of unstable medical condition * Acute psychiatric decompensation or severity of symptoms requiring psychiatric hospitalization in past 6 months * Diagnosis of schizoaffective or bipolar affective disorder, dementia, or intellectual disability * Current episode of major depressive disorder (MDD) * Use of mood stabilizer, clozapine, and/or daily benzodiazepine * Current moderate or severe substance use disorder
Reproduced word-for-word from the public registry record — the study team can answer questions about it.
| Site 5038 | Garden Grove, California, United States | Recruiting |
| Site 5063 | Los Angeles, California, United States | Recruiting |
| Site 5106 | Orange, California, United States | Recruiting |
| Site 5035 | Walnut Creek, California, United States | Recruiting |
| Site 5060 | Hollywood, Florida, United States | Recruiting |
| Site 5015 | Tampa, Florida, United States | Recruiting |
| Site 5064 | Snellville, Georgia, United States | Recruiting |
| Site 5056 | Chicago, Illinois, United States | Recruiting |
| Site 5062 | Gaithersburg, Maryland, United States | Recruiting |
| Site 5124 | Belmont, Massachusetts, United States | Recruiting |
| Site 5108 | New York, New York, United States | Recruiting |
| Site 5077 | New York, New York, United States | Recruiting |
+ 2 more locations — full list on the registry record.
This study lists sites in the areas below. Each link shows other recruiting studies near that city, from the public registry record.
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Source record: clinicaltrials.gov/study/NCT06502964