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Study identifier: NCT06456346 Synced from ClinicalTrials.gov · August 06, 2026
● Study status: Active Not Recruiting

Bomedemstat vs Hydroxyurea for Essential Thrombocythemia (MK-3543-007)

Condition: Essential Thrombocythemia  ·  Sponsor: Merck Sharp & Dohme LLC

PhasePhase 3
Planned participants300
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The purpose of this study is to evaluate the efficacy and safety of bomedemstat compared with hydroxyurea in cytoreductive therapy naïve essential thrombocythemia (ET) participants for whom cytoreductive therapy is indicated. Its primary objective is to compare bomedemstat to hydroxyurea with respect to durable clinicohematologic response (DCHR). The primary hypothesis is that bomedemstat is superior to hydroxyurea with respect to DCHR.

This description comes directly from the study's public registry record.

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No contact information is available for this study as per the public registry record.

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Locations (171)

Palo Verde Cancer Specialists ( Site 0052)Glendale, Arizona, United States
Los Angeles Cancer Network ( Site 0025)Glendale, California, United States
Stanford Cancer Center ( Site 0024)Palo Alto, California, United States
Exempla Lutheran Medical Center ( Site 0014)Golden, Colorado, United States
Yale University School of Medicine ( Site 0051)New Haven, Connecticut, United States
Parkview Research Center at Parkview Regional Medical Center ( Site 0006)Fort Wayne, Indiana, United States
University of Michigan ( Site 0003)Ann Arbor, Michigan, United States
Optum Care Cancer Center ( Site 0053)Las Vegas, Nevada, United States
Levine Cancer Institute ( Site 0009)Charlotte, North Carolina, United States
Duke University Health System (DUHS) ( Site 0012)Durham, North Carolina, United States
Wake Forest Baptist Health-Internal Medicine, Section on Hematology & Oncology ( Site 0013)Winston-Salem, North Carolina, United States
The Ohio State University Wexner Medical Center ( Site 0028)Columbus, Ohio, United States

+ 159 more locations — full list on the registry record.

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