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Study identifier: NCT06422143 Synced from ClinicalTrials.gov · August 05, 2026
● Study status: Recruiting

Pembrolizumab With or Without Maintenance Sacituzumab Tirumotecan (Sac-TMT; MK-2870) in Metastatic Squamous Non-small Cell Lung Cancer (NSCLC) [MK-2870-023]

Condition: Non-small Cell Lung Cancer · NSCLC  ·  Sponsor: Merck Sharp & Dohme LLC

PhasePhase 3
Planned participants851
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This is a phase 3 study of pembrolizumab in combination with carboplatin/taxane (paclitaxel or nab-paclitaxel) followed by pembrolizumab with or without maintenance sacituzumab tirumotecan (sac-TMT; MK-2870) in first-line treatment of metastatic squamous non-small cell lung cancer. It is hypothesized that pembrolizumab with maintenance sacituzumab tirumotecan is superior to pembrolizumab without sacituzumab tirumotecan maintenance with respect to overall survival (OS).

This description comes directly from the study's public registry record.

Talk to the study team

Toll Free Number  ·  1-888-577-8839  ·  Trialsites@msd.com

Always discuss trial participation with your own doctor first.

Locations (215)

CARTI Cancer Center ( Site 0006)Little Rock, Arkansas, United StatesRecruiting
Roy and Patricia Disney Family Cancer Center - Providence Saint Joseph Medical Center ( Site 0122)Burbank, California, United StatesRecruiting
Sharp Memorial Hospital ( Site 9544)San Diego, California, United StatesRecruiting
Intermountain Health Cancer Center Lutheran Hospital ( Site 0119)Golden, Colorado, United StatesRecruiting
Intermountain Health St. Mary's Regional Hospital ( Site 0116)Grand Junction, Colorado, United StatesRecruiting
Washington Hospital Center ( Site 0037)Washington D.C., District of Columbia, United StatesRecruiting
Mid Florida Hematology and Oncology Center ( Site 0109)Orange City, Florida, United StatesCompleted
Centricity Research Columbus Cancer Center ( Site 0111)Columbus, Georgia, United StatesCompleted
Northwest Georgia Oncology Centers, a Service of Wellstar Cobb Hospital ( Site 0001)Marietta, Georgia, United StatesCompleted
Southeastern Regional Medical Center ( Site 0004)Newnan, Georgia, United StatesCompleted
University of Chicago Medical Center ( Site 0145)Chicago, Illinois, United StatesRecruiting
Trinity Health Saint Joseph Mercy Hospital Ann Arbor ( Site 9552)Ypsilanti, Michigan, United StatesRecruiting

+ 203 more locations — full list on the registry record.

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