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Study identifier: NCT06378177 Synced from ClinicalTrials.gov · August 07, 2026
● Study status: Active Not Recruiting

A Study of LVGN6051 Combination Therapy in Patient With Head and Neck Squamous Cell Carcinoma (HNSCC)

Condition: Head and Neck Squamous Cell Carcinoma  ·  Sponsor: Lyvgen Biopharma Holdings Limited

PhasePhase 2
Planned participants64
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The purpose of this study is to assess the safety and efficacy of LVGN6051 (4-1BB agonistic antibody) combined with toripalimab (anti-PD-1 antibody) and paclitaxel (anti-tubulin chemotherapy) in patients with recurrent/metastatic head and neck squamous cell carcinoma who rapidly progress from previous neoadjuvant, curative, or adjuvant platinum-containing therapy, or who are currently contraindicated for platinum-containing treatment.

This description comes directly from the study's public registry record.

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No contact information is available for this study as per the public registry record.

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Locations (16)

Anhui Cancer HospitalHefei, Anhui, China
Beijing Cancer HospitalBeijing, Beijing Municipality, China
Beijing Tongren Hospital Affiliated to Capital Medical UniversityBeijing, Beijing Municipality, China
Fujian cancer hospitalFuzhou, Fujian, China
Sun Yat-sen Memorial Hospital, Sun Yat-sen UniversityGuangzhou, Guangdong, China
Guangxi Medical University Cancer HospitalNanning, Guangxi, China
Henan cancer hospitalZhengzhou, Henan, China
Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyWuhan, Hubei, China
Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyWuhan, Hubei, China
Xiangya Hospital Central South UniversityChangsha, Hunan, China
The Second Xiangya Hospital, Central South UniversityChangsha, Hunan, China
Hunan Cancer HospitalChangsha, Hunan, China

+ 4 more locations — full list on the registry record.

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