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Study identifier: NCT06352359 Synced from ClinicalTrials.gov · August 07, 2026
● Study status: Recruiting

Safety, Pharmacokinetics (PK), and Efficacy of ONC 841 in Advanced Solid Tumors

Condition: Advanced Solid Tumor  ·  Sponsor: OncoC4, Inc.

PhasePhase 1
Planned participants72
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This is a Phase I/II open label study of intravenous (IV) infusion of ONC-841 as a single agent or in combination in patients with advanced/metastatic solid tumors. The study will evaluate seven dose levels of ONC-841. The Phase 1 part is dose escalation with 7 dose levels of ONC-841 and the dose expansion in the last dose level. The Phase 2 part will test the combination of ONC-841 with SOC in GBM and in CRC.

This description comes directly from the study's public registry record.

Talk to the study team

Pan Zheng, MD, PhD  ·  (240) 552-5193  ·  pzheng@oncoc4.com

Imaan Khan, MD  ·  ikhan@oncoc4.com

Always discuss trial participation with your own doctor first.

Locations (8)

University of California at Davis Cancer CenterSacramento, California, United StatesRecruiting
UF Health Cancer Center, University of FloridaGainesville, Florida, United StatesRecruiting
AdventHealth Medical Group Oncology Research at CelebrationKissimmee, Florida, United StatesRecruiting
Norton Cancer CenterLouisville, Kentucky, United StatesRecruiting
Rogel Cancer Center, University of MichiganAnn Arbor, Michigan, United StatesRecruiting
Thomas Jefferson University HospitalPhiladelphia, Pennsylvania, United StatesRecruiting
MD Anderson Cancer CenterHouston, Texas, United StatesRecruiting
Huntsman Cancer Institute, University of UtahSalt Lake City, Utah, United StatesRecruiting

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