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Study identifier: NCT06343298 Synced from ClinicalTrials.gov · August 07, 2026
● Study status: Recruiting

To Evaluate the Safety and Efficacy of MANP in Subjects With Difficult to Control/ Resistant Hypertension

Condition: Difficult to Control Hypertension  ·  Sponsor: E-Star BioTech, LLC

PhasePhase 2
Planned participants120
Who can joinAll sexes, 18 Years to 80 Years
Healthy volunteersNo

Sponsor, CRO or site team? See where this study is running → — listed sites, countries and recruiting context. Everything below is written for patients and caregivers.

About this study

This is a Phase 2 dose-titration study designed to evaluate the safety and efficacy of MANP subcutaneous injection compared to placebo in reducing baseline daytime systolic blood pressure (SBP), derived from 24-hour ambulatory blood pressure monitoring (ABPM), in subjects with hypertension who are taking 3 or more antihypertensive medications with different mechanisms of action.

This description comes directly from the study's public registry record.

Talk to the study team

Seetha R Iyer, MS  ·  212-271-4295  ·  sri@icw.ventures

Lucia Gonzalez

Always discuss trial participation with your own doctor first.

Locations (29)

Lynn Institute of the OzarksLittle Rock, Arkansas, United StatesRecruiting
Amicis Research Center - Beverly HillsBeverly Hills, California, United StatesRecruiting
Amicis Research Center - Granada HillsGranada Hills, California, United StatesRecruiting
Orange County Research CenterLake Forest, California, United StatesRecruiting
Amicis Research Center - PalmdalePalmdale, California, United StatesRecruiting
Amicis Research Site - ValenciaValencia, California, United StatesRecruiting
Interventional Cardiology Medical GroupWest Hills, California, United StatesWithdrawn
Office of Dr. Edward Portnoy MDWestlake Village, California, United StatesRecruiting
SM Research CenterBiscayne Park, Florida, United StatesRecruiting
Arrow Clinical TrialsDaytona Beach, Florida, United StatesRecruiting
Royal Research CorpHollywood, Florida, United StatesRecruiting
Evolution Clinical TrialsMiami, Florida, United StatesRecruiting

+ 17 more locations — full list on the registry record.

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