EICHORCondition: Hypertension · Sponsor: Swansea University
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Hypertension is the most important cause of cardiovascular disease (CVD), stroke, and premature death (WHO, 2021). It is estimated by The World Health Organisation in 2021 that 1.4 billion individuals across the globe have high blood pressure, with only 14% of people actively managing these elevated levels. Simple and effective lifestyle strategies are required to help people improve their blood pressure and/or attenuate increases in blood pressure with ageing. Physical activity is one possible strategy: in previous research, several different types of physical activity have been shown to have beneficial effects on blood pressure (Blackwell et al., 2017). However, many individuals do not adhere to currently recommended levels of physical activity (150 mins of moderate intensity physical activity per week), due to a combination of the required time commitment, lack of motivation, and the associated levels of effort, exertion, and physical discomfort (Korkiakangas et al 2009). Thus, there is a need to identify alternative exercise interventions which will overcome these barriers but remain effective at improving blood pressure (Herrod, Lund, \& Phillips, 2021, Toohey et al, 2018). Low intensity isometric hand grip exercise training (IET) has been shown to result in large decreases in resting blood pressure in younger and older age groups, in both men and women, and in individuals with normal as well as elevated baseline blood pressure (Badrov et al, 2013; Bentley et al., 2018;…
This description comes directly from the study's public registry record.
Richard Metcalfe, PhD · 01792205678 · r.s.metcalfe@swansea.ac.uk
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Inclusion Criteria: * Aged between 18 and 65 years. * Scoring low or moderate on the international physical activity questionnaire (IPAQ). * Previous diagnosis of high blood pressure and/or a resting systolic blood pressure ≥130 but \<180 mmHg (self-reported and confirmed during screening/baseline assessment). * Currently taking no anti-hypertensive medicine or taking anti-hypertensive medicine with no treatment change within the last 4 months prior to enrollment. * Stable dietary and physical activity patterns (including dietary supplementation) over the last 4 months Exclusion Criteria: * Aged \<18 or \>65 years * Resting blood pressure ≥180/110 mmHg or resting heart rate \>100 bpm during baseline as-sessment * Manifest cardiovascular disease including cerebrovascular disease, heart failure, chronic kidney disease, peripheral vascular disease, or advanced retinopathy (fundus hypertonicus grades III-IV) based on a self-report health history questionnaire. * Type 1 diabetes * History of other chronic disease including malignancy, neurological conditions (e.g. multiple sclerosis) or respiratory conditions (e.g. COPD). * Contraindications to exercise based on answers to the physical activity readiness questionnaire. * Physical limitations preventing handgrip exercise (e.g. arthritis or other musculoskeletal disorder) * Scoring "high" on the international physical activity questionnaire * Taking more than 2 anti-hypertensive drugs or a change in treatment strategy in the previous 4 months. * Currently taking nitrate medication (as it is commonly prescribed for angina) or on hormone replacement therapy * Significant self-reported change in lifestyle patterns in the prior 4 months (e.g. currently on a planned diet for weight loss).
Reproduced word-for-word from the public registry record — the study team can answer questions about it.
| Swansea University | Swansea, Wales, United Kingdom | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06335433