EICHORCondition: Parkinson Disease · Sponsor: Glaceum
1. Study Objective \- To assess the efficacy and safety of vutiglabridin in early Parkindson's disease patients 2. Background Glaceum Inc. has evaluated the safety, tolerability, and pharmacokinetic/pharmacodynamic properties of vutiglabridin in healthy subjects through its Phase 1 trials, and is planning to perform this Phase 2a trial to assess the efficacy and safety of vutiglabridin in early Parkinson's disease patients. 3. Study Design and Protocol This study is a randomized, double-blind, placebo-controlled, parallel-group trial. Subjects deemed eligible to participate in this study based on the inclusion/exclusion criteria will be assigned a subject number and randomized to one of the 3 treatment groups - 1 group receiving a placebo - in a 1:1:1 ratio. Subjects will be randomized to double-blind treatments and will receive a once-daily oral dose of the investigational product for 24 weeks according to the study protocol. Several parameters (i.e., MDS-UPDRS, CGI-C, K-NMSS, modified Hoehn-Yahr stage and SNBR) will be evaluated to assess the efficacy of vutiglabridin. Assessments including measurement of vital signs, 12-lead ECG, clinical laboratory test, pregnancy test, physical examination, and adverse event monitoring will be performed to evaluate the safety and tolerability of vutiglabridin. Blood samples will be collected for pharmacokinetic assessment.
This description comes directly from the study's public registry record.
No contact information is available for this study as per the public registry record.
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| Hallym University Medical Center | Anyang-si, Gyeonggi-do, South Korea | — |
| The Catholic University of Korea Uijeongbu St.Marys Hostpial | Uijeongbu-si, Gyeonggi-do, South Korea | — |
| Inje University Busan Paik Hospital | Busan, South Korea | — |
| Inje University Sanggye Paik Hospital | Seoul, South Korea | — |
| KyungHee University Medical Center | Seoul, South Korea | — |
| Severance Hospital | Seoul, South Korea | — |
| Samsung Medical Center | Seoul, South Korea | — |
| The Catholic University of Korea | Seoul, South Korea | — |
| Korea University Guro Hospital | Seoul, South Korea | — |
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Source record: clinicaltrials.gov/study/NCT06329141