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Study identifier: NCT06299098 Synced from ClinicalTrials.gov · August 07, 2026
● Study status: Active Not Recruiting

A Study to Test if Trevogrumab or Trevogrumab With Garetosmab When Taken With Semaglutide is Safe and How Well They Work in Adult Patients With Obesity for Weight Loss, Fat Loss, and Lean Mass Preservation

Condition: Obesity  ·  Sponsor: Regeneron Pharmaceuticals

PhasePhase 2
Planned participants1005
Who can joinAll sexes, 18 Years to 80 Years
Healthy volunteersYes

About this study

This study is researching experimental drugs called trevogrumab and garetosmab (called "study drugs") in combination with another drug, semaglutide (Wegovy®). This study will be done in 3 parts, Part A, Part B, and Part C where different study drugs will be tested. Part A of the study is focused on healthy participants. Part B and C of the study is focused on participants with obesity. The aim of Part A of the study is to see how safe and tolerable the study drug is in healthy participants. The aim of Part B and Part C of the study is to see how safe and effective the study drug is when combined with Wegovy. Parts A, B, and C of the study are looking at several other research questions, including: * What side effects may happen from taking the study drug * How much study drug is in the blood at different times * Whether the body makes antibodies against the study drug (which could make the drug less effective or could lead to side effects)

This description comes directly from the study's public registry record.

Talk to the study team

No contact information is available for this study as per the public registry record.

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Locations (60)

Pinnacle Research GroupAnniston, Alabama, United States
Cullman Clinical TrialsCullman, Alabama, United States
Foothills Research Center Cct ResearchPhoenix, Arizona, United States
Anaheim Clinical TrialsAnaheim, California, United States
ProScientoChula Vista, California, United States
Valiance Clinical Research- Huntington ParkHuntington Park, California, United States
Velocity, San DiegoLa Mesa, California, United States
Northern California ResearchSacramento, California, United States
Acclaim Clinical ResearchSan Diego, California, United States
Metabolic Institute of AmericaTarzana, California, United States
Valiance Clinical ResearchTarzana, California, United States
Southwest General Healthcare CenterFort Myers, Florida, United States

+ 48 more locations — full list on the registry record.

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