EICHORCondition: Anorexia Nervosa · Sponsor: Karolinska Institutet
Experimental and genetic data, as well as brain imaging, support a role of the hypothalamic Arcuate nucleus neurons and their communication with surrounding microglia in anorectic conditions, but it has until recently not been possible to explore these cells at a molecular level in anorexia nervosa (AN) patients. This attributed to the obvious lack of valid tissue and non-invasive imaging techniques of high enough resolution. Stem cell models have evolved as a useful tool for the exploration of other neuropsychiatric disorders with a comparably high genetic contribution as AN. The investigators will here use patient-derived induced pluripotent stem cells (iPSCs) to profile Arc neurons and peripheral blood mononuclear cell (PBMC) derived microglia in AN, thus defining molecules to explore as drug targets.
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Inclusion Criteria anorexia nervosa: * female * 18-45 years of age * AN restrictive diagnosis as main diagnosis * more than 5 years duration Exclusion Criteria anorexia nervosa: \- Inclusion Criteria healthy control: * female * 18-45 years of age * BMI 18,5 - 25 Exclusion Criteria healthy control: * own or family member with eating disorder diagnosis * own or family member with autism diagnosis
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| Karolinska Institutet | Stockholm, Sweden | — |
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Source record: clinicaltrials.gov/study/NCT06259500