EICHORCondition: Lung Cancer · Sponsor: Catharina Ziekenhuis Eindhoven
Interested? Contact the study team ↓
Despite scientific evidence, use of liquid biopsy (LB) in diagnosis and monitoring of lung cancer (LC) is limited since it requires major changes in diagnostic and care pathways. Analyzing tumor markers (TMs), circulating tumor cells (CTCs) and circulating tumor DNA (ctDNA) in blood (LB) can inform about the nature of the tumor, the most appropriate therapy, therapy response and resistance. Lungmarker2 is a multicenter, prospective, implementation and diagnostic cohort study. This study aims to implement up-front ctDNA analysis ('plasma first approach') into routine diagnostic work-up of all advanced stage LC patients in the Southeast of the Netherlands (the participating hospitals in the OncoZON region). Thereby, additional information about the molecular make-up of the tumor becomes available, the number of tissue Next-Generation Sequencing (NGS) analyses will decrease and time to therapeutic decision making is shortened. Next, using ctDNA, TM and other information, multi-parametric decision support models are built and validated that may support diagnosis, predict the outcome of the next imaging procedure and progression-free survival during follow-up. The final goal is to develop a super-resolution microscopy test that can detect PD-L1 expression on CTCs.
This description comes directly from the study's public registry record.
Hao Cao, MSc · +31402398644 · hao.cao@catharinaziekenhuis.nl
Volkher Scharnhorst, Prof.Dr. · +31402398640 · volkher.scharnhorst@catharinaziekenhuis.nl
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Always discuss trial participation with your own doctor first.
Inclusion Criteria: * Aged 18 or above and suspected of having lung cancer Exclusion Criteria: * Presence of another malignant tumor, i.e. diagnosed with a tumor in the past 5 years
Reproduced word-for-word from the public registry record — the study team can answer questions about it.
| Zuyderland Medical Center | Heerlen, Limburg, Netherlands | Not Yet Recruiting |
| Maastricht University Medical Center | Maastricht, Limburg, Netherlands | Not Yet Recruiting |
| Catharina Ziekenhuis Eindhoven | Eindhoven, North Brabant, Netherlands | Recruiting |
| St. Anna Ziekenhuis | Geldrop, North Brabant, Netherlands | Not Yet Recruiting |
| Máxima Medisch Centrum | Veldhoven, North Brabant, Netherlands | Not Yet Recruiting |
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Source record: clinicaltrials.gov/study/NCT06105177