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Study identifier: NCT06079879 Synced from ClinicalTrials.gov · August 06, 2026
● Study status: Active Not Recruiting

A Study of Bomedemstat (IMG-7289/MK-3543) Compared to Best Available Therapy (BAT) in Participants With Essential Thrombocythemia and an Inadequate Response or Intolerance of Hydroxyurea (MK-3543-006)

Condition: Essential Thrombocythemia  ·  Sponsor: Merck Sharp & Dohme LLC

PhasePhase 3
Planned participants340
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This is a study evaluating the safety and efficacy of bomedemstat (MK-3543) compared with the best available therapy (BAT) in participants with essential thrombocythemia (ET) who have an inadequate response to or are intolerant of hydroxyurea. The primary study hypothesis is that bomedemstat is superior to the best available therapy with respect to durable clinicohematologic response (DCHR).

This description comes directly from the study's public registry record.

Talk to the study team

No contact information is available for this study as per the public registry record.

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Locations (163)

Palo Verde Hematology/ Oncology Center, Ltd. ( Site 3496)Glendale, Arizona, United States
Los Angeles Cancer Network ( Site 3491)Glendale, California, United States
Stanford Cancer Institute ( Site 0107)Stanford, California, United States
The Lundquist Institute ( Site 3423)Torrance, California, United States
University of Colorado Anschutz Medical Campus ( Site 3425)Aurora, Colorado, United States
Tufts Medical Center ( Site 3408)Boston, Massachusetts, United States
University of Michigan ( Site 0008)Ann Arbor, Michigan, United States
Henry Ford Hospital ( Site 3413)Detroit, Michigan, United States
Optum Care Cancer Center ( Site 3497)Las Vegas, Nevada, United States
Roswell Park Cancer Institute ( Site 3421)Buffalo, New York, United States
Duke University Health System (DUHS) ( Site 0016)Durham, North Carolina, United States
Wake Forest Baptist Health-Internal Medicine, Section on Hematology & Oncology ( Site 3400)Winston-Salem, North Carolina, United States

+ 151 more locations — full list on the registry record.

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