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Study identifier: NCT05996835 Synced from ClinicalTrials.gov · August 07, 2026
● Study status: Completed

Phase 2b Study to Investigate the Safety and Efficacy of TIN816 in Sepsis-associated Acute Kidney Injury (CLEAR-AKI)

Condition: Acute Kidney Injury Due to Sepsis  ·  Sponsor: Novartis Pharmaceuticals

PhasePhase 2
Planned participants316
Who can joinAll sexes, 18 Years to 85 Years
Healthy volunteersNo

About this study

The purpose of this Ph2b study is to characterize the dose-response relationship and to evaluate the safety and efficacy of three different single doses of TIN816 in hospitalized adult participants in an intensive care setting with a diagnosis of sepsis-associated acute kidney injury (SA-AKI).

This description comes directly from the study's public registry record.

Talk to the study team

No contact information is available for this study as per the public registry record.

Always discuss trial participation with your own doctor first.

Locations (79)

University Of AlabamaBirmingham, Alabama, United States
UC San Francisco Medical CenterSan Francisco, California, United States
Stanford HealthcareStanford, California, United States
Emory Johns Creek HospitalJohns Creek, Georgia, United States
Northwestern Memorial HospitalEvanston, Illinois, United States
Univ Of Iowa Hospitals And ClinicsIowa City, Iowa, United States
Massachusetts General HospitalBoston, Massachusetts, United States
Beth Israel Deaconess Med CenterBoston, Massachusetts, United States
Lahey Hospital and Medical CenterBurlington, Massachusetts, United States
Baystate Medical CenterSpringfield, Massachusetts, United States
Mayo Clinic RochesterRochester, Minnesota, United States
Montefiore Medical CenterThe Bronx, New York, United States

+ 67 more locations — full list on the registry record.

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