EICHORCondition: Locally Advanced (Unresectable) or Metastatic Solid Tumors · Sponsor: Txinno Bioscience Inc.
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This is a phase I clinical trial to primarily evaluate the safety, tolerability, and addtionally assess pharmacokinetics, pharmacodynamics, and antitumor activity of investigational product, TXN10128. The target subjects will be consisted of patients with locally advanced (unresectable) or metastatic soild tumors. This study includes a dose-escalation part and a dose-expansion part, and a TXN10128 monotherapy part and a TXN10128 + Irinotecan or Paclitaxel combination therapy part.
This description comes directly from the study's public registry record.
Eun-Young Kwak, Ph.D. · 82 31 778 8688 · bella@txinno.com
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Inclusion Criteria: * Male or female subjects ≥19 years of age at the time of informed consent. * Histologically and/or cytologically confirmed any progressive, locally advanced (unresectable), or metastatic solid tumors that have relapsed or are refractory following the last line of treatment and for which prior standard therapy has been ineffective, or standard therapy does not exist or is not considered appropriate. * ECOG performance status of 0 or 1. * Life expectancy of at least 12 weeks. Exclusion Criteria: * Has leptomeningeal disease. * Experienced a Grade ≥3 immune-related adverse events (irAE) with prior immunotherapy with the exception of non-clinically significant laboratory abnormalities. * Prior organ transplantation. * Known positive human immunodeficiency virus (HIV) infection.
Reproduced word-for-word from the public registry record — the study team can answer questions about it.
| Seoul National University Bundang Hospital | Seongnam-si, Gyeonggi-do, South Korea | Recruiting |
| Chungbuk National University Hospital | Cheonju, North Chungcheong, South Korea | Recruiting |
| Seoul National Univ. Hospital | Seoul, Seoul, South Korea | Recruiting |
| Asan Medical Center | Seoul, Seoul, South Korea | Recruiting |
| Gachon University Gil Medical Center | Incheon, South Korea | Recruiting |
| SAMSUNG Medical Center | Seoul, South Korea | Recruiting |
This study lists sites in the areas below. Each link shows other recruiting studies near that city, from the public registry record.
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Source record: clinicaltrials.gov/study/NCT05978492