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Study identifier: NCT05971940 Synced from ClinicalTrials.gov · August 08, 2026
● Study status: CompletedACHIEVE-1

A Study of Orforglipron (LY3502970) in Adult Participants With Type 2 Diabetes and Inadequate Glycemic Control With Diet and Exercise Alone

Condition: Type 2 Diabetes  ·  Sponsor: Eli Lilly and Company

PhasePhase 3
Planned participants559
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNoCheck eligibility criteria ↓
Where89 locations · 6 countries

Sponsor, CRO or site team? See where this study is running → — listed sites, countries and recruiting context. Everything below is written for patients and caregivers.

About this study

The main purpose of this study is to determine safety and efficacy of orforglipron compared with placebo in adult participants with type 2 diabetes and inadequate glycemic control with diet and exercise alone. The study will last approximately 54 weeks.

This description comes directly from the study's public registry record.

Talk to the study team

No contact information is available for this study as per the public registry record.

Always discuss trial participation with your own doctor first.

Full eligibility criteria (exactly as the study team wrote them)

Inclusion Criteria: * Have Type 2 Diabetes * Have HbA1c ≥7.0% (53 mmol/mol) to ≤9.5% (80 mmol/mol) despite diet and exercise treatment, as determined by the central laboratory at screening. * Are naïve to insulin therapy except for gestational diabetes or ≤14 days use for acute treatment and have not used any oral or injectable antihyperglycemic medications during the 90 days preceding screening or between screening and randomization. * Are of stable weight (±5%) for at least 90 days prior to screening and agree to not initiate an intensive diet or exercise program during the study with the intent of reducing body weight other than the lifestyle and/or dietary measures for diabetes treatment. * Have a body mass index (BMI) ≥23.0 kilogram/square meter (kg/m²) at screening. Exclusion Criteria: * Have Type 1 Diabetes * Have a history of ketoacidosis or hyperosmolar state or coma within the last 6 months prior to screening, or between screening and randomization. * Currently receiving or planning to receive treatment for diabetic retinopathy and/or macular edema * Have New York Heart Association functional classification IV congestive heart failure. * Have acute or chronic pancreatitis

Reproduced word-for-word from the public registry record — the study team can answer questions about it.

Locations (89)

Syed Research Consultants LlcSheffield, Alabama, United States
Epic Medical Research - SurpriseSurprise, Arizona, United States
Quality of Life Medical & Research CenterTucson, Arizona, United States
Neighborhood Healthcare Institute of HealthEscondido, California, United States
Velocity Clinical Research, Huntington ParkHuntington Park, California, United States
Ark Clinical ResearchLong Beach, California, United States
Velocity Clinical Research, WestlakeLos Angeles, California, United States
Infinity Clinical Research - NorcoNorco, California, United States
Norcal Endocrinology & Internal MedicineSan Ramon, California, United States
University Clinical Investigators, Inc.Tustin, California, United States
Connecticut Clinical Research - CromwellCromwell, Connecticut, United States
Invictus Clinical Research GroupCoconut Creek, Florida, United States

+ 77 more locations — full list on the registry record.

More studies in these areas

This study lists sites in the areas below. Each link shows other recruiting studies near that city, from the public registry record.

SheffieldSurpriseTucsonEscondido

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