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Study identifier: NCT05937178 Synced from ClinicalTrials.gov · August 07, 2026
● Study status: Recruiting

Real-world Study Optimizing Nucleotide-analogues

Condition: Hepatitis B, Chronic  ·  Sponsor: Huashan Hospital

PhaseN/A
Planned participants20000
Who can joinAll sexes, 18 Years to 80 Years
Healthy volunteersNo

Sponsor, CRO or site team? See where this study is running → — listed sites, countries and recruiting context. Everything below is written for patients and caregivers.

About this study

The goal of this multicenter, observational, prospective study is to observe and compare different anti-viral treatment strategies in a real-world cohort of patients with CHB managed in routine clinical settings in China. The main questions it aims to answer are: 1. To evaluate the benefits of initiating first-line nucleos(t)ide analogue in patients with chronic HBV infection who are recommended in the updated Chinese Guideline 2022, but not recommended in the Chinese Guideline 2019. 2. To evaluate the Chinese Guideline recommends initiation of treatment, but at least one foreign authoritative guideline (eg. AASLD, EASL) does not recommend the benefit of initiating first-line nucleos(t)ide analogue in patients with chronic HBV infection who initiate treatment. 3. To compare the treatment effect of different alternatives with patients who have partial response after treatment with first-line nucleos(t)ide analogues.

This description comes directly from the study's public registry record.

Talk to the study team

Wenghong Zhang, MD  ·  13801844344  ·  zhangwenhong@fudan.edu.cn

Always discuss trial participation with your own doctor first.

Locations (44)

Anhui Provincial HospitalHefei, Anhui, ChinaNot Yet Recruiting
The First Affiliated Hospital of Anhui Medical UniversityHefei, Anhui, ChinaNot Yet Recruiting
Beijing YouAn HospitaBeijing, Beijing Municipality, ChinaNot Yet Recruiting
Peking University First HospitalBeijing, Beijing Municipality, ChinaRecruiting
Peking University People's HospitalBeijing, Beijing Municipality, ChinaNot Yet Recruiting
The Second Affiliated Hospital of Chongqing Medical UniversityChongqing, Chongqing Municipality, ChinaNot Yet Recruiting
the Southwest Hospital of AMUChongqing, Chongqing Municipality, ChinaNot Yet Recruiting
First Affiliated Hospital of Fujian Medical UniversityFuzhou, Fujian, ChinaNot Yet Recruiting
Xiamen Hospital of Traditional Chinese MedicineXiamen, Fujian, ChinaNot Yet Recruiting
the First Hospital of Lanzhou UniversityLanzhou, Gansu, ChinaNot Yet Recruiting
First Affiliated Hospital of Guangxi Medical UniversityNanning, Guangxi, ChinaNot Yet Recruiting
The Affiliated Hospital Of Guizhou Medical UniversityGuiyang, Guizhou, ChinaNot Yet Recruiting

+ 32 more locations — full list on the registry record.

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