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Study identifier: NCT05779631 Synced from ClinicalTrials.gov · August 08, 2026
● Study status: RecruitingBladParadigm

Multi-parametric MRI in Patients Suspected for Muscle Invasive Bladder Cancer: a New Local Staging Paradigm

Condition: Bladder Cancer · Muscle-invasive Bladder Cancer  ·  Sponsor: Radboud University Medical Center

PhaseNA
Planned participants360
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNoCheck eligibility criteria ↓
Where19 locations

Interested? Contact the study team ↓

Sponsor, CRO or site team? See where this study is running → — listed sites, countries and recruiting context. Everything below is written for patients and caregivers.

About this study

A two-arm multicenter randomised controlled trial, comparing progression free survival, time to definitive treatment and cost-effectiveness of the standard of care (TURBT) and mpMRI followed by same-day cystoscopic bladder biopsy for diagnosis of patients with suspicion of muscle-invasive bladder cancer.

This description comes directly from the study's public registry record.

Talk to the study team

A. G. van der Heijden, Dr.  ·  +31 (0)24 361 37 35  ·  toine.vanderheijden@radboudumc.nl

There is no obligation to join — the study team can answer your questions about taking part.

Always discuss trial participation with your own doctor first.

Full eligibility criteria (exactly as the study team wrote them)

Inclusion Criteria: * Patients (18+ years of age) * Clinically suspected MIBC * No lymph node or distant metastases * Written informed consent Exclusion Criteria: * Unable or unwilling to undergo mpMRI * Unfit for TURBT * Unfit for definitive treatment with curative intent * A history of cancer, including bladder cancer, except: non-melanoma skin cancer, prostate cancer on active surveillance or a solid malignant tumor ≥5 years disease-free since last treatment

Reproduced word-for-word from the public registry record — the study team can answer questions about it.

Locations (19)

Jeroen Bosch ziekenhuis's-Hertogenbosch, NetherlandsRecruiting
Ziekenhuisgroep TwenteAlmelo, NetherlandsRecruiting
Meander MCAmersfoort, NetherlandsNot Yet Recruiting
Amsterdam UMC, location AMCAmsterdam, NetherlandsRecruiting
Amsterdam UMC, location VUmcAmsterdam, NetherlandsRecruiting
Antoni van Leeuwenhoek - Netherlands Cancer InstituteAmsterdam, NetherlandsRecruiting
OLVGAmsterdam, NetherlandsRecruiting
Rijnstate ziekenhuisArnhem, NetherlandsRecruiting
Maasziekenhuis PanteinBoxmeer, NetherlandsRecruiting
Ziekenhuis Gelderse ValleiEde, NetherlandsRecruiting
TreantEmmen, NetherlandsNot Yet Recruiting
Medisch Spectrum TwenteEnschede, NetherlandsNot Yet Recruiting

+ 7 more locations — full list on the registry record.

More studies in these areas

This study lists sites in the areas below. Each link shows other recruiting studies near that city, from the public registry record.

's-HertogenboschAlmeloAmsterdamArnhem

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