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Study identifier: NCT05738486 Synced from ClinicalTrials.gov · August 06, 2026
● Study status: Active Not Recruiting

A Study of Different Donanemab (LY3002813) Dosing Regimens in Adults With Early Alzheimer's Disease (TRAILBLAZER-ALZ 6)

Condition: Alzheimer's Disease · Dementia · Brain Diseases  ·  Sponsor: Eli Lilly and Company

PhasePhase 3
Planned participants1175
Who can joinAll sexes, 60 Years to 85 Years
Healthy volunteersNo

About this study

This study will investigate different donanemab dosing regimens and their effect on the frequency and severity of ARIA-E in adults with early symptomatic Alzheimer's disease (AD) and explore participant characteristics that might predict risk of ARIA. Approximately 375 additional participants will be enrolled in addendum 2. Addendum 3 includes a subset of participants from the main study to receive a single dose. The study will last approximately 91 weeks and include up to 26 visits in the main study.

This description comes directly from the study's public registry record.

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No contact information is available for this study as per the public registry record.

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Locations (49)

MD First Research - ChandlerChandler, Arizona, United States
Irvine Clinical ResearchIrvine, California, United States
Healthy Brain ClinicLong Beach, California, United States
California Neuroscience Research Medical Group, Inc.Sherman Oaks, California, United States
JEM Research InstituteAtlantis, Florida, United States
VIN-Julie SchwartzbardAventura, Florida, United States
Excel Medical Clinical TrialsBoca Raton, Florida, United States
K2 Medical ResearchClermont, Florida, United States
Brain Matters ResearchDelray Beach, Florida, United States
Neuropsychiatric Research Center of Southwest FloridaFort Myers, Florida, United States
Finlay Medical ResearchGreenacres City, Florida, United States
Infinity Clinical Research, LLCHollywood, Florida, United States

+ 37 more locations — full list on the registry record.

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