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Study identifier: NCT05599191 Synced from ClinicalTrials.gov · August 08, 2026
● Study status: CompletedCALM-1

A 52-Week Study of the Efficacy and Safety of BLU-5937 in Adults With Refractory Chronic Cough

Condition: Cough · Refractory Chronic Cough  ·  Sponsor: Bellus Health Inc. - a GSK company

PhasePhase 3
Planned participants957
Who can joinAll sexes, 18 Years to 80 Years
Healthy volunteersNoCheck eligibility criteria ↓
Where200 locations · 15 countries

Sponsor, CRO or site team? See where this study is running → — listed sites, countries and recruiting context. Everything below is written for patients and caregivers.

About this study

This is a randomized, double-blind, placebo-controlled, parallel-arm, Phase 3 study of BLU-5937 in participants with Refractory Chronic Cough (RCC).

This description comes directly from the study's public registry record.

Talk to the study team

No contact information is available for this study as per the public registry record.

Always discuss trial participation with your own doctor first.

Full eligibility criteria (exactly as the study team wrote them)

Inclusion Criteria: * Capable of giving signed informed consent * Refractory chronic cough (including unexplained chronic cough) for at least one year * Women of child-bearing potential must use a highly effective contraception method during the study and for at least 14 days after the last dose Exclusion Criteria: * Current smoker/vaper (all forms of smoking and inhaled substances, including, cannabis/tobacco smoke and nicotine vapors) or individuals who have given up smoking within the past 6 months, or those with \>20 pack-year smoking history * Diagnosis of chronic obstructive pulmonary disease, bronchiectasis, chronic bronchitis, cystic fibrosis, pulmonary sarcoidosis, idiopathic pulmonary fibrosis, uncontrolled asthma, or other significant or progressive airway/respiratory disorder that might affect cough based on clinician assessment * Respiratory tract infection within 4 weeks before screening * Laboratory confirmed Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection at screening * History of malignancy in the last 5 years * History of alcohol or drug abuse within the last 3 years * Has a positive serologic test for human immunodeficiency virus (HIV), hepatitis B virus surface antigen, or hepatitis C virus. * Previous participation in a BLU-5937 trial

Reproduced word-for-word from the public registry record — the study team can answer questions about it.

Locations (200)

GSK Investigational SiteJasper, Alabama, United States
GSK Investigational SiteLitchfield Park, Arizona, United States
GSK Investigational SiteScottsdale, Arizona, United States
GSK Investigational SiteLittle Rock, Arkansas, United States
GSK Investigational SiteEncinitas, California, United States
GSK Investigational SiteMission Viejo, California, United States
GSK Investigational SiteParamount, California, United States
GSK Investigational SiteRoseville, California, United States
GSK Investigational SiteAurora, Colorado, United States
GSK Investigational SiteColorado Springs, Colorado, United States
GSK Investigational SiteClearwater, Florida, United States
GSK Investigational SiteGainesville, Florida, United States

+ 188 more locations — full list on the registry record.

More studies in these areas

This study lists sites in the areas below. Each link shows other recruiting studies near that city, from the public registry record.

JasperLitchfield ParkScottsdaleLittle Rock

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