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Study identifier: NCT05582538 Synced from ClinicalTrials.gov · August 07, 2026
● Study status: Recruiting

Restoring Sensitivity To Immunotherapy In Advanced Triple Negative Breast Cancer Exploiting Ceralasertib Priming Followed By Combined Durvalumab/Nab-Paclitaxel

Condition: Triple Negative Breast Cancer Metastatic  ·  Sponsor: IFOM ETS - The AIRC Institute of Molecular Oncology

PhasePhase 2
Planned participants37
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

Sponsor, CRO or site team? See where this study is running → — listed sites, countries and recruiting context. Everything below is written for patients and caregivers.

About this study

This study will evaluate the efficacy and safety of ceralasertib followed by durvalumab plus nab-paclitaxel in 37 patients with TNBC, whose tumor relapsed following treatment with curative intent for early disease, which must have included immunotherapy and chemotherapy as part of the radical locoregional therapy (either adjuvant, neoadjuvant or both).

This description comes directly from the study's public registry record.

Talk to the study team

Ylenia Silvestri, PhD  ·  +3902574303797  ·  clinical.trials@ifom.eu

Smeralda Rapisarda, PhD  ·  +3902574303236  ·  clinical.trials@ifom.eu

Always discuss trial participation with your own doctor first.

Locations (6)

Azienda Ospedaliero Universitaria Maggiore della CaritàNovara, Novara, ItalyRecruiting
ASST Papa Giovanni XXIIIBergamo, ItalyRecruiting
Istituto Nazionale dei Tumori IRCCSMilan, ItalyRecruiting
IRCCS Istituto Nazionale Tumori "Fondazione Giovanni Pascale"Naples, ItalyRecruiting
Istituto Oncologico Veneto IRCCSPadova, ItalyRecruiting
Azienda U.S.L. - IRCCS di Reggio EmiliaReggio Emilia, ItalyRecruiting

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