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Study identifier: NCT05545007 Synced from ClinicalTrials.gov · August 07, 2026
● Study status: Recruiting

Preoperative vs Postoperative Hypofractionated Radiosurgery for Patients With Large Brain Metastases

Condition: Brain Metastases, Adult  ·  Sponsor: Istituto Clinico Humanitas

PhaseNA
Planned participants146
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

Sponsor, CRO or site team? See where this study is running → — listed sites, countries and recruiting context. Everything below is written for patients and caregivers.

About this study

This is a phase III randomized trial with the aim to compare preoperative HSRS to postoperative HSRS in patients with large at least one BMs from solid tumors suitable for surgical resection.

This description comes directly from the study's public registry record.

Talk to the study team

Pierina Navarria, MD  ·  +39 028224 7458  ·  pierina.navarria@cancercenter.humanitas.it

Federico Pessina, MD  ·  +39 028224 4617  ·  federico.pessina@hunimed.eu

Always discuss trial participation with your own doctor first.

Locations (9)

ASST Spedali Civili di BresciaBrescia, Brescia, ItalyRecruiting
AOUC Azienda Ospedaliero-Universitaria CareggiFlorence, Florence, ItalyRecruiting
IRCCS Istituto Clinico HumanitasRozzano, Milano, ItalyRecruiting
Fondazione IRCCS Istituto Neurologico Carlo BestaMilan, Milan, ItalyRecruiting
Ospedale del MareNaples, Naples, ItalyRecruiting
Policlinico Umberto IRome, Rome, ItalyActive Not Recruiting
Fondazione Policlinico Universitario Agostino GemelliRome, Rome, ItalyRecruiting
AOU Sant'AndreaRome, Rome, ItalyRecruiting
Azienda Ospedaliera Santa Maria di TerniTerni, Terni, ItalyRecruiting

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