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Study identifier: NCT05471856 Synced from ClinicalTrials.gov · August 07, 2026
● Study status: Recruiting

A Study to Test How Different Doses of BI 1703880 in Combination With Ezabenlimab Are Tolerated in People With Different Types of Advanced Cancer (Solid Tumours)

Condition: Solid Tumors  ·  Sponsor: Boehringer Ingelheim

PhasePhase 1
Planned participants66
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

Sponsor, CRO or site team? See where this study is running → — listed sites, countries and recruiting context. Everything below is written for patients and caregivers.

About this study

This study is open to adults with different types of advanced cancer. People can take part if previous treatment was not successful, or no treatment exists. The purpose of this study is to find the highest dose of a medicine called BI 1703880 that people with advanced cancer can tolerate when taken together with ezabenlimab. BI 1703880 and ezabenlimab are medicines that may help the immune system fight cancer. In this study, BI 1703880 is given to people for the first time. Participants get BI 1703880 and ezabenlimab as infusions into a vein. During the first 6 weeks, they get BI 1703880 once a week. Later, they get BI 1703880 every 3 weeks. After the first 3 weeks, they get ezabenlimab in addition every 3 weeks. Participants can get BI 1703880 for up to 1 year and ezabenlimab for up to 2 years as long as they benefit from treatment and can tolerate it. During this time, they visit the study site regularly. At these visits, the doctors check participants' health and take note of any unwanted effects.

This description comes directly from the study's public registry record.

Talk to the study team

Boehringer Ingelheim  ·  1-800-243-0127  ·  clintriage.rdg@boehringer-ingelheim.com

Always discuss trial participation with your own doctor first.

Locations (13)

Valkyrie Clinical TrialsLos Angeles, California, United StatesRecruiting
Yale University School of MedicineNew Haven, Connecticut, United StatesRecruiting
John Theurer Cancer CenterHackensack, New Jersey, United StatesRecruiting
National Cancer Center Hospital EastChiba, Kashiwa, JapanRecruiting
Saitama Medical University International Medical CenterSaitama, Hidaka, JapanRecruiting
Japanese Foundation for Cancer ResearchTokyo, Koto-ku, JapanRecruiting
Hospital Universitari Vall d'HebronBarcelona, SpainRecruiting
CIO Clara CampalMadrid, SpainRecruiting
Instituto Valenciano de OncologíaValencia, SpainRecruiting
Hospital Clinico Universitario de ValenciaValencia, SpainRecruiting
The Royal Marsden Hospital, ChelseaLondon, United KingdomRecruiting
Churchill HospitalOxford, United KingdomRecruiting

+ 1 more locations — full list on the registry record.

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