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Study identifier: NCT05467748 Synced from ClinicalTrials.gov · August 07, 2026
● Study status: Recruiting

EZH2 Inhibitor, Tulmimetostat, and PD-1 Blockade for Treatment of Advanced Non-small Cell Lung Cancer

Condition: Non Small Cell Lung Cancer  ·  Sponsor: VA Office of Research and Development

PhasePhase 1/Phase 2
Planned participants66
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

Sponsor, CRO or site team? See where this study is running → — listed sites, countries and recruiting context. Everything below is written for patients and caregivers.

About this study

This is an open label, single arm, phase Ib/II clinical trial of checkpoint blockade, pembrolizumab and EZH2 inhibitor, tulmimetostat combination therapy for patients with advanced non-small cell lung cancer who have progressed from front or second-line treatment. Patients will be enrolled at multiple Veterans Affairs Medical Centers.

This description comes directly from the study's public registry record.

Talk to the study team

Daniel S Shin, MD PhD  ·  (713) 578-4126  ·  Daniel.Shin@va.gov

Quillan Huang, MD  ·  (713) 791-1414  ·  Quillan.Huang@va.gov

Always discuss trial participation with your own doctor first.

Locations (5)

VA Long Beach Healthcare System, Long Beach, CALong Beach, California, United StatesNot Yet Recruiting
VA Northern California Health Care System, Mather, CASacramento, California, United StatesNot Yet Recruiting
VA San Diego Healthcare System, San Diego, CASan Diego, California, United StatesRecruiting
VA Ann Arbor Healthcare System, Ann Arbor, MIAnn Arbor, Michigan, United StatesRecruiting
Michael E. DeBakey VA Medical Center, Houston, TXHouston, Texas, United StatesRecruiting

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