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Study identifier: NCT05411198 Synced from ClinicalTrials.gov · August 07, 2026
● Study status: Completed

Study to Assess Change in Disease Activity and Adverse Events of Ab Externo Approach for Glaucoma Gel Stent (XEN45) Implantation In Participants Aged 45 Years or Older With Open-Angle Glaucoma

Condition: Open-Angle Glaucoma  ·  Sponsor: AbbVie

PhasePhase 3
Planned participants74
Who can joinAll sexes, 45 Years to no upper limit
Healthy volunteersNo

Sponsor, CRO or site team? See where this study is running → — listed sites, countries and recruiting context. Everything below is written for patients and caregivers.

About this study

Glaucoma is the second most common cause of blindness in the world, second only to cataracts. This study will assess how safe and effective a glaucoma gel stent is when implanted using the ab externo approach. Adverse events and intraocular pressure will be assessed. XEN45 is an approved device for the treatment of glaucoma implanted using the ab interno approach (inside the eye). XEN45 implanted using the ab externo approach (outside the eye) is being studied in this study. Approximately 65 participants aged 45 years or older with open-angle glaucoma will be enrolled in this study at approximately 22 sites in the United States. All participants will receive XEN45 implanted using the ab externo approach on Day 1 and will be followed for 12 months. Participants will attend regular visits during the study at a hospital or clinic. The safety and effect of the gel stent on your glaucoma will be checked by medical assessments and eye examinations.

This description comes directly from the study's public registry record.

Talk to the study team

No contact information is available for this study as per the public registry record.

Always discuss trial participation with your own doctor first.

Locations (25)

Vold Vision /ID# 245285Fayetteville, Arkansas, United States
UCLA Doheny Eye Center /ID# 227587Pasadena, California, United States
Ventura Ophthalmology /ID# 227585Ventura, California, United States
East Coast Institute for Research /ID# 255508Jacksonville, Florida, United States
Center for Sight - Sarasota /ID# 227577Sarasota, Florida, United States
New Vision Eye Center /ID# 261053Vero Beach, Florida, United States
Georgia Eye Partners /ID# 245203Atlanta, Georgia, United States
Stiles Eyecare Excellence /ID# 227576Overland Park, Kansas, United States
The Johns Hopkins Wilmer Eye Institute - Bethesda /ID# 245355Bethesda, Maryland, United States
Vance Thompson Vision /ID# 261125Alexandria, Minnesota, United States
Washington University-School of Medicine /ID# 245452St Louis, Missouri, United States
NYU Langone Medical Center /ID# 227583New York, New York, United States

+ 13 more locations — full list on the registry record.

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