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Study identifier: NCT05279092 Synced from ClinicalTrials.gov · August 07, 2026
● Study status: Recruiting

Yale Steroid Enhanced Versus Exparel Nerveblock TKA RCT Study

Condition: Total Knee Replacement · Knee Arthroplasty  ·  Sponsor: Yale University

PhasePhase 2
Planned participants250
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

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About this study

The objective of this phase 2 study is to investigate the efficacy of Dexamethasone sodium phosphate (DEX) plus Methylprednisolone acetate (MPA) in combination with plain bupivacaine (B) compared with Liposomal Bupivacaine (LB) in combination with plain bupivacaine on post-surgical pain control among patients undergoing unilateral total knee arthroplasty (TKA) to asses if perineural B-DEX-MPA will result in superior analgesia efficacy as compared to B-LB. This study will also assess if perineural B-DEX-MPA results in improved quality of postoperative recovery as compared to B-LB.

This description comes directly from the study's public registry record.

Talk to the study team

Jinlei Li, MD PhD  ·  475-434-4038  ·  jinlei.li@yale.edu

Always discuss trial participation with your own doctor first.

Locations (2)

Yale New Haven Hospital Saint Raphael CampusNew Haven, Connecticut, United StatesRecruiting
Yale New Haven Hospital York Street CampusNew Haven, Connecticut, United StatesRecruiting

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