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Study identifier: NCT05268614 Synced from ClinicalTrials.gov · August 07, 2026
● Study status: Recruiting

Risk Adapted De-Intensification of Radio-Chemotherapy for Oropharyngeal Squamous Cell Carcinoma

Condition: Oropharyngeal Squamous Cell Carcinoma  ·  Sponsor: University of Florida

PhasePhase 2
Planned participants250
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

Sponsor, CRO or site team? See where this study is running → — listed sites, countries and recruiting context. Everything below is written for patients and caregivers.

About this study

This study builds on the results of several prior studies that we have been involved with to test the hypothesis that Risk-Adapted De-Intensification of Radiation Therapy and chemotherapy based on HPV subtype, plasma circulating free HPV DNA (cfHPV DNA) level, and cfHPV DNA clearance rate produces Local-Regional Control rates that are similar to what has been achieved with more aggressive therapy in patients with Favorable Prognosis Oropharyngeal Squamous Cell Carcinoma (OPSCC).

This description comes directly from the study's public registry record.

Talk to the study team

Teresa Ware, MPH  ·  352-273-5739  ·  PMO@cancer.ufl.edu

Always discuss trial participation with your own doctor first.

Locations (3)

University of FloridaGainesville, Florida, United StatesRecruiting
UF Health Proton Therapy InstituteJacksonville, Florida, United StatesRecruiting
Medical University of South CarolinaCharleston, South Carolina, United StatesRecruiting

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