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Study identifier: NCT05164094 Synced from ClinicalTrials.gov · August 08, 2026
● Study status: Active Not Recruiting

A Study of an Epstein-Barr Virus (EBV) Candidate Vaccine, mRNA-1189, in 10- to 30-Year-Old Healthy Adolescents and Adults

Condition: Epstein-Barr Virus Infection  ·  Sponsor: ModernaTX, Inc.

PhasePhase 1/Phase 2
Planned participants867
Who can joinAll sexes, 10 Years to 30 Years
Healthy volunteersYesCheck eligibility criteria ↓
Where65 locations

Sponsor, CRO or site team? See where this study is running → — listed sites, countries and recruiting context. Everything below is written for patients and caregivers.

About this study

The main objective of Part A of this trial is to evaluate the safety and reactogenicity of mRNA-1189 in 18- to 30-year-old healthy adults, the main objective of Part B is to evaluate the safety and reactogenicity of mRNA-1189 in 12- to \<18-year-old healthy EBV-seronegative adolescents, and the main objective of Part C is to evaluate the safety and reactogenicity of mRNA-1189 in 10- to 21-year-old healthy adolescents and adults.

This description comes directly from the study's public registry record.

Talk to the study team

No contact information is available for this study as per the public registry record.

Always discuss trial participation with your own doctor first.

Full eligibility criteria (exactly as the study team wrote them)

Inclusion Criteria: * According to the assessment of the investigator, is in good general health and can comply with study procedures. Part A: Healthy adult from 18 to 30 years of age (inclusive) at the time of consent (Screening Visit, Day 0). Part B: Healthy baseline EBV-seronegative adolescents from 12 to \<18 years of age at the time of consent (Screening Visit, Day 0). Part C: Healthy adolescents and adults from 10 to 21 years of age (inclusive) at the time of consent (Screening Visit, Day 0). Exclusion Criteria: * Has had significant exposure to someone with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection or COVID-19 in the past 14 days prior to the screening visit, if the participant has not been fully vaccinated against COVID-19 at least 14 days prior to the screening visit. * Has symptomatic acute or chronic illness requiring ongoing medical or surgical care, to include changes in medication in the past 2 months indicating that chronic illness/disease is not stable (at the discretion of the investigator). * Significant, progressive, unstable or uncontrolled clinical condition, including any condition that may affect participant safety, assessment of study endpoints, assessment of immune response, or adherence to study procedures per investigator judgement. * Has a history of myocarditis, and/or pericarditis. * Has received or plans to receive any licensed or authorized vaccine, to include COVID-19 vaccines, ≤28 days prior to the first injection (Day 1) or plans to receive a licensed vaccine within 28 days before or after any study vaccine injection, with the exception of licensed influenza vaccines, which may be received more than 14 days before or after any study vaccine injection. Note: Other inclusion and exclusion criteria may apply.

Reproduced word-for-word from the public registry record — the study team can answer questions about it.

Locations (65)

Medical Affiliated Research InstituteHuntsville, Alabama, United States
Smart Cures Clinical ResearchAnaheim, California, United States
Benchmark Research - Colton - HyperCore - PPDSColton, California, United States
Fomat Medical ResearchOxnard, California, United States
Center For Clinical Trials LLC -ParamountParamount, California, United States
Artemis Institute For Clinical Research LLC - Riverside - Headlands - PPDSRiverside, California, United States
Peninsula Research Associates - Headlands Research - PPDSRolling Hills, California, United States
Velocity Clinical Research - Banning - PPDSSan Bernardino, California, United States
Acclaim Clinical ResearchSan Diego, California, United States
California Research Foundation - 4180 Ruffin RdSan Diego, California, United States
Orange County Research CenterTustin, California, United States
CenExel iResearch, LLCHollywood, Florida, United States

+ 53 more locations — full list on the registry record.

More studies in these areas

This study lists sites in the areas below. Each link shows other recruiting studies near that city, from the public registry record.

HuntsvilleAnaheimColtonOxnard

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