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Study identifier: NCT05152147 Synced from ClinicalTrials.gov · August 06, 2026
● Study status: Active Not Recruiting

A Study of Zanidatamab in Combination With Chemotherapy Plus or Minus Tislelizumab in Patients With HER2-positive Advanced or Metastatic Gastric and Esophageal Cancers

Condition: Gastric Neoplasms · Gastroesophageal Adenocarcinoma · Esophageal Adenocarcinoma  ·  Sponsor: Jazz Pharmaceuticals

PhasePhase 3
Planned participants920
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This study is being done to find out if zanidatamab, when given with chemotherapy plus or minus tislelizumab, is safe and works better than trastuzumab given with chemotherapy. The patients in this study will have advanced human epidermal growth factor 2 (HER2)-positive stomach and esophageal cancers that are no longer treatable with surgery (unresectable) or chemoradiation, and/or have grown or spread to other parts of the body (metastatic).

This description comes directly from the study's public registry record.

Talk to the study team

No contact information is available for this study as per the public registry record.

Always discuss trial participation with your own doctor first.

Locations (227)

Hospital de Gastroenterología Dr Bonorino UdaondoBuenos Aires, Argentina
Instituto de Investigaciones Metabólicas - IDIMBuenos Aires, Argentina
Hospital Italiano de Buenos AiresBuenos Aires, Argentina
Fundación Centro de Medicina Nuclear y Molecular ERCórdoba, Argentina
Centro Médico Privado CEMAICCórdoba, Argentina
Centro de Investigación Pergamino S.A.Pergamino, Argentina
Centro de Investigación Clínica - Clínica ViedmaViedma, Argentina
Flinders Medical CentreBedford Park, Australia
Austin HealthHeidelberg, Australia
Liverpool HospitalLiverpool, Australia
Fiona Stanley HospitalMurdoch, Australia
Imelda VZWBonheiden, Belgium

+ 215 more locations — full list on the registry record.

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