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Study identifier: NCT05093634 Synced from ClinicalTrials.gov · August 06, 2026
● Study status: Completed

EMANATE: A Study of Setmelanotide in Patients With Specific Gene Variants in the MC4R Pathway

Condition: Obesity · Genetic Obesity  ·  Sponsor: Rhythm Pharmaceuticals, Inc.

PhasePhase 3
Planned participants296
Who can joinAll sexes, 6 Years to 65 Years
Healthy volunteersNo

Sponsor, CRO or site team? See where this study is running → — listed sites, countries and recruiting context. Everything below is written for patients and caregivers.

About this study

The protocol describes a randomized, double-blind, placebo-controlled trial with independent sub-studies of setmelanotide in patients with obesity and at least one of the specific gene variants in the Melanocortin-4 Receptor pathway: * POMC or PCSK1 (Sub-study 035a) * LEPR (Sub-study 035b) * SRC1 (Sub-study 035c) * SH2B1 (Sub-study 035d) The objectives and endpoints are identical for these sub-studies.

This description comes directly from the study's public registry record.

Talk to the study team

No contact information is available for this study as per the public registry record.

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Locations (56)

Phoenix Children's HospitalPhoenix, Arizona, United States
HonorHealth Bariatric CenterScottsdale, Arizona, United States
Children's Hospital Los AngelesLos Angeles, California, United States
Children's Hospital ColoradoAurora, Colorado, United States
Yale Center for Clinical InvestigationNew Haven, Connecticut, United States
Advent HealthAltamonte Springs, Florida, United States
InQuest Medical ResearchSuwanee, Georgia, United States
UMASS Memorial Medical CenterWorcester, Massachusetts, United States
University of MichiganAnn Arbor, Michigan, United States
Metro Detroit Endocrinology CenterDearborn, Michigan, United States
Mayo ClinicRochester, Minnesota, United States
St. Luke's HospitalChesterfield, Missouri, United States

+ 44 more locations — full list on the registry record.

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