EICHORCondition: Alveolar Rhabdomyosarcoma · Botryoid-Type Embryonal Rhabdomyosarcoma · Embryonal Rhabdomyosarcoma · Sponsor: Children's Oncology Group
This phase III trial compares the safety and effect of adding vinorelbine to vincristine, dactinomycin, and cyclophosphamide (VAC) for the treatment of patients with high risk rhabdomyosarcoma (RMS). High risk refers to cancer that is likely to recur (come back) after treatment or spread to other parts of the body. This study will also examine if adding maintenance therapy after VAC therapy, with or without vinorelbine, will help get rid of the cancer and/or lower the chance that the cancer comes back. Vinorelbine and vincristine are in a class of medications called vinca alkaloids. They work by stopping cancer cells from growing and dividing and may kill them. Dactinomycin is a type of antibiotic that is only used in cancer chemotherapy. It works by damaging the cell's deoxyribonucleic acid (DNA) and may kill cancer cells. Cyclophosphamide is in a class of medications called alkylating agents. It works by damaging the cell's DNA and may kill cancer cells. It may also lower the body's immune response. Vinorelbine, vincristine, dactinomycin and cyclophosphamide are chemotherapy medications that work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. This trial may have the potential to eliminate rhabdomyosarcoma for a long time or for the rest of patient's life.
This description comes directly from the study's public registry record.
No contact information is available for this study as per the public registry record.
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| Children's Hospital of Alabama | Birmingham, Alabama, United States | — |
| USA Health Strada Patient Care Center | Mobile, Alabama, United States | — |
| Providence Alaska Medical Center | Anchorage, Alaska, United States | — |
| Kingman Regional Medical Center | Kingman, Arizona, United States | — |
| Banner Children's at Desert | Mesa, Arizona, United States | — |
| Phoenix Childrens Hospital | Phoenix, Arizona, United States | — |
| Banner University Medical Center - Tucson | Tucson, Arizona, United States | — |
| Arkansas Children's Hospital | Little Rock, Arkansas, United States | — |
| Kaiser Permanente-Anaheim | Anaheim, California, United States | — |
| PCR Oncology | Arroyo Grande, California, United States | — |
| Kaiser Permanente-Bellflower | Bellflower, California, United States | — |
| Kaiser Permanente Downey Medical Center | Downey, California, United States | — |
+ 238 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT04994132