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Study identifier: NCT04970901 Synced from ClinicalTrials.gov · August 06, 2026
● Study status: Active Not Recruiting

A Study to Evaluate the Safety and Anti-cancer Activity of Loncastuximab Tesirine in Combination With Other Anti-cancer Agents in Participants With Relapsed or Refractory B-cell Non-Hodgkin Lymphoma (LOTIS-7)

Condition: B-Cell Non-Hodgkin Lymphoma · Relapsed B-Cell Non-Hodgkin Lymphoma · Refractory B-Cell Non-Hodgkin Lymphoma  ·  Sponsor: ADC Therapeutics S.A.

PhasePhase 1
Planned participants154
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The primary objective of this study is to characterize the safety and tolerability of loncastuximab tesirine in combination with polatuzumab vedotin, glofitamab, or mosunetuzumab, and to identify the maximum tolerated dose (MTD) and/or recommended dose for expansion (RDE) for the combinations.

This description comes directly from the study's public registry record.

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No contact information is available for this study as per the public registry record.

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Locations (40)

University of California San Francisco - Fresno Center for Medical Education and ResearchClovis, California, United States
Scripps Health - Prebys Cancer CenterSan Diego, California, United States
Sylvester Comprehensive Cancer CenterMiami, Florida, United States
Miami Cancer InstituteMiami, Florida, United States
Memorial Cancer Institute - Memorial Hospital WestPembroke Pines, Florida, United States
Winship Cancer Institute of Emory UniversityAtlanta, Georgia, United States
The Blood and Marrow Transplant Group of GeorgiaAtlanta, Georgia, United States
Mission Cancer + Blood - Mission Cancer FoundationDes Moines, Iowa, United States
Beth Israel Deaconess Medical CenterBoston, Massachusetts, United States
Dana-Farber Cancer InstituteBoston, Massachusetts, United States
University of MinnesotaMinneapolis, Minnesota, United States
Columbia University Irving Medical CenterNew York, New York, United States

+ 28 more locations — full list on the registry record.

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