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Study identifier: NCT04843761 Synced from ClinicalTrials.gov · August 06, 2026
● Study status: Completed

ACTIV-3b: Therapeutics for Severely Ill Inpatients With COVID-19

Condition: Covid19  ·  Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

PhasePhase 3
Planned participants473
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This study looks at the safety and effectiveness of different drugs in treating COVID-19 in people who have been hospitalized with the infection and who have acute respiratory failure. Participants in the study will be treated with either a study drug plus current standard of care (SOC), or with placebo plus current SOC. Substudy H1: Aviptadil for Severely Ill Inpatients With COVID-19 (NCT06729606) Substudy H2: Remdesivir for Severely Ill Inpatients With COVID-19 (NCT06729593)

This description comes directly from the study's public registry record.

Talk to the study team

No contact information is available for this study as per the public registry record.

Always discuss trial participation with your own doctor first.

Locations (40)

Banner University Medical Center Tucson (Site 206-004), 1625 N. Campbell AvenueTucson, Arizona, United States
UCSF Fresno (Site 203-005), 155 N. Fresno StreetFresno, California, United States
VA Loma Linda Healthcare System (Site 074-017), 11201 Benton StreetLoma Linda, California, United States
Cedars-Sinai Medical Center (Site 208-002), 8700 Beverly BoulevardLos Angeles, California, United States
Ronald Reagan UCLA Medical Center (Site 203-002), 757 Westwood PlazaLos Angeles, California, United States
UCSF Medical Center at Mount Zion (Site 203-007), 1600 Divisadero St.San Francisco, California, United States
UCSF Medical Center (Site 203-001), Moffit-Long Hospital, 505 Parnassus Ave.San Francisco, California, United States
Stanford University Hospital & Clinics (Site 203-003), 300 Pasteur Dr.Stanford, California, United States
University of Colorado Hospital (Site 204-001), 12605 E. 16th AvenueAurora, Colorado, United States
Denver Health Medical Center (Site 204-004), 780 Delaware Street, Pavilion BDenver, Colorado, United States
MedStar Health Research Institute (Site 009-021), 110 Irving St., NW.Washington D.C., District of Columbia, United States
Washington DC VA Medical Center (Site 009-004), 50 Irving Street, NW.Washington D.C., District of Columbia, United States

+ 28 more locations — full list on the registry record.

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