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Study identifier: NCT04821778 Synced from ClinicalTrials.gov · August 07, 2026
● Study status: Recruiting

Chemoradiotherapy in Esophageal or Esophagogastric Junction Cancer

Condition: Esophagus Cancer · Esophagogastric Junction Cancer · Chemoradiation  ·  Sponsor: Cancer Institute and Hospital, Chinese Academy of Medical Sciences

PhasePhase 3
Planned participants2000
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

Sponsor, CRO or site team? See where this study is running → — listed sites, countries and recruiting context. Everything below is written for patients and caregivers.

About this study

Definitive chemoradiotherapy is the standard of care in unresectable esophageal or esophagogastric cancer. A multidisciplinary approach, including chemotherapy and radiotherapy, is important for these patients. Morerover, molecular targeting agents does not show clear efficacy in EC up to now. Nowadays, the pace of development of cancer immunotherapies is accelerating. Clinical evidence of the efficacy of immune checkpoint inhibitors and adoptive immunotherapies herald the onset of a new era in cancer immunotherapy. There have also been recent developments to provide a promising frontier in extending the use of immunotherpay or targeting agents to radiotherapy. The purpose of this study was to explore the optimal treatment modalities including PD-1/PD-L1 antibody or targeted drug for patients with unresectable esophageal or esophagogastric junction cancer.

This description comes directly from the study's public registry record.

Talk to the study team

Xin Wang, MD  ·  +861013311583220  ·  beryl_wx2000@163.com

Always discuss trial participation with your own doctor first.

Locations (5)

Department 4th of Radiation Oncology, Anyang Cancer HospitalAnyang, Henan, ChinaRecruiting
Hunan Cancer Hospital, the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South UniversityChangsha, Hunan, ChinaRecruiting
Department of Radiation oncology, Jiangsu Cancer Hospital/Jiangsu Institute of Cancer Research/The affiliated Cancer Hospital of Nanjing Medical UniversityNanjing, Jiangsu, ChinaRecruiting
Department of Radiation oncology, Jiangsu Province Hospital/The First Affiliated Hospital with Nanjing Medical UniversityNanjing, Jiangsu, ChinaRecruiting
Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC)Beijing, ChinaRecruiting

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