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Study identifier: NCT04714320 Synced from ClinicalTrials.gov · August 06, 2026
● Study status: Completed

A Study to Assess the Safety, Tolerability and Efficacy of IONIS-AGT-LRx in Hypertensive Participants With Uncontrolled Blood Pressure

Condition: Hypertension  ·  Sponsor: Ionis Pharmaceuticals, Inc.

PhasePhase 2
Planned participants160
Who can joinAll sexes, 18 Years to 80 Years
Healthy volunteersNo

About this study

The purpose of this study was to evaluate the effect of IONIS-AGT-LRx compared to placebo on seated automated office systolic blood pressure (SBP) from baseline to Study Day 85 in uncontrolled hypertensive participants on ≥ 3 antihypertensive medications and to evaluate the effect of IONIS-AGT-LRx on ambulatory blood pressure, seated automated office SBP, seated automated office diastolic blood pressure (DBP), and plasma angiotensinogen (AGT) at each scheduled visit in uncontrolled hypertensive participants on ≥ 3 antihypertensive medications.

This description comes directly from the study's public registry record.

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No contact information is available for this study as per the public registry record.

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Locations (50)

Pinnacle Research GroupAnniston, Alabama, United States
Central Research Associates, Inc.Birmingham, Alabama, United States
Achieve Clinical Research, LLCBirmingham, Alabama, United States
Cahaba Research, Inc.Pelham, Alabama, United States
Syed Research Consultants LLCSheffield, Alabama, United States
Cardiology and Medicine ClinicLittle Rock, Arkansas, United States
Advanced Research CenterAnaheim, California, United States
National Research Institute - Huntington ParkHuntington Park, California, United States
RESPIRE ResearchLa Mesa, California, United States
Clinical Trials ResearchLincoln, California, United States
Catalina Research InstituteMontclair, California, United States
San Fernando Valley Health InstituteVan Nuys, California, United States

+ 38 more locations — full list on the registry record.

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