EichorEICHOR
Study identifier: NCT04652700 Synced from ClinicalTrials.gov · August 07, 2026
● Study status: Terminated

Oral Islatravir (MK-8591) Once-Monthly as Preexposure Prophylaxis (PrEP) in Men and Transgender Women Who Are at High Risk for HIV-1 Infection (MK-8591-024)

Condition: HIV Preexposure Prophylaxis  ·  Sponsor: Merck Sharp & Dohme LLC

PhasePhase 3
Planned participants494
Who can joinMale, 16 Years to no upper limit
Healthy volunteersYes

About this study

The main purpose of the study is to evaluate the safety and tolerability of oral Islatravir (ISL) once monthly (QM) as Preexposure Prophylaxis (PrEP) in cisgender men who have sex with men (MSM) and transgender women (TGW) who have sex with men and who are at high risk of HIV-1 infection with 48 or 96 weeks of treatment and a minimum follow-up of 42 days.

This description comes directly from the study's public registry record.

Talk to the study team

No contact information is available for this study as per the public registry record.

Always discuss trial participation with your own doctor first.

Locations (25)

University of Alabama at Birmingham-UAB 1917 Research Clinic ( Site 0007)Birmingham, Alabama, United States
UCLA Center for Clinical AIDS Research and Education ( Site 0011)Los Angeles, California, United States
Global Research Institute ( Site 0031)Los Angeles, California, United States
Bridge HIV - San Francisco Department of Public Health ( Site 0003)San Francisco, California, United States
The GW Medical Faculty Associates-Medicine ( Site 0033)Washington D.C., District of Columbia, United States
Midway Immunology and Research Center ( Site 0014)Ft. Pierce, Florida, United States
University of Miami Miller School of Medicine-Infectious Disease ( Site 0029)Miami, Florida, United States
Orlando Immunology Center ( Site 0010)Orlando, Florida, United States
Ponce De Leon Center Grady Health ( Site 0032)Atlanta, Georgia, United States
Howard Brown Health Center ( Site 0004)Chicago, Illinois, United States
The University of Mississippi Medical Center ( Site 0012)Jackson, Mississippi, United States
Rutgers New Jersey Medical School-Clinical Research Center ( Site 0017)Newark, New Jersey, United States

+ 13 more locations — full list on the registry record.

Follow this study

Get one email when the public record changes — results posted, or the study's status changes. Nothing else, ever.

We email about this public record only. Unsubscribe anytime with one click. Never medical advice. By subscribing you agree to our Terms of Use and Privacy Policy.

Is this your study? This page was generated automatically from the public registry record. Sponsors can claim it — free — to add branding and verified contact routing. Claim this page →