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Study identifier: NCT04622319 Synced from ClinicalTrials.gov · August 07, 2026
● Study status: Active Not Recruiting

A Study of Trastuzumab Deruxtecan (T-DXd) Versus Trastuzumab Emtansine (T-DM1) in High-risk HER2-positive Participants With Residual Invasive Breast Cancer Following Neoadjuvant Therapy (DESTINY-Breast05)

Condition: HER2-Positive Primary Breast Cancer · Residual Invasive Breast Cancer  ·  Sponsor: Daiichi Sankyo

PhasePhase 3
Planned participants1600
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

Sponsor, CRO or site team? See where this study is running → — listed sites, countries and recruiting context. Everything below is written for patients and caregivers.

About this study

Patients with HER2-positive primary breast cancer (BC) who do not achieve complete response after appropriate neoadjuvant therapy are at higher risk of disease recurrence. More effective treatment options are needed for this patient population. This study will examine the efficacy and safety of trastuzumab deruxtecan (T-DXd) compared with trastuzumab emtansine (T-DM1) in high-risk patients with residual invasive breast cancer following neoadjuvant therapy.

This description comes directly from the study's public registry record.

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No contact information is available for this study as per the public registry record.

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Locations (482)

The Oncology Institute of Hope & InnovationAnaheim, California, United States
Kaiser PermanenteAnaheim, California, United States
Kaiser PermanenteBaldwin Park, California, United States
Kaiser PermanenteBellflower, California, United States
Kaiser PermanenteFontana, California, United States
Orange Coast Blood and Cancer CareFountain Valley, California, United States
Kaiser PermanenteHarbor City, California, United States
Kaiser PermanenteIrvine, California, United States
Long Beach Memorial TCILong Beach, California, United States
Kaiser PermanenteLos Angeles, California, United States
Kaiser PermanenteOntario, California, United States
Kaiser PermanentePanorama City, California, United States

+ 470 more locations — full list on the registry record.

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