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Study identifier: NCT04597008 Synced from ClinicalTrials.gov · August 07, 2026
● Study status: Completed

Topical Antibiotic Therapy to Reduce Infection After Operative Treatment of Fractures at High Risk of Infection: TOBRA

Condition: Post Operative Surgical Site Infection  ·  Sponsor: Major Extremity Trauma Research Consortium

PhasePhase 3
Planned participants1660
Who can joinAll sexes, 18 Years to 80 Years
Healthy volunteersNo

About this study

The overall objective is to compare the effect of Vancomycin and Tobramycin powder combined (treatment) to Vancomycin powder (control) in the reduction of post-fixation infections of tibial plateau and tibial pilon fractures at high risk of infection (collectively considered the "study injuries").

This description comes directly from the study's public registry record.

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No contact information is available for this study as per the public registry record.

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Locations (41)

University of Alabama Heersink School of MedicineBirmingham, Alabama, United States
Keck School of Medicine of USCLos Angeles, California, United States
Stanford UniversityRedwood City, California, United States
_University of California, San FranciscoSan Francisco, California, United States
Cedars SinaiWest Hollywood, California, United States
University of Colorado Anschutz Medical CampusAurora, Colorado, United States
St Mary's University/Tenent HealthWest Palm Beach, Florida, United States
Loyola University ChicagoChicago, Illinois, United States
Indiana University School of Medicine - Methodist HospitalIndianapolis, Indiana, United States
Indiana University/Eskenazi HealthIndianapolis, Indiana, United States
University of KentuckyLexington, Kentucky, United States
LSU Health SciencesNew Orleans, Louisiana, United States

+ 29 more locations — full list on the registry record.

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