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Study identifier: NCT04475939 Synced from ClinicalTrials.gov · August 07, 2026
● Study status: Completed

Placebo-controlled Study Comparing Niraparib Plus Pembrolizumab Versus Placebo Plus Pembrolizumab as Maintenance Therapy in Participants With Advanced/Metastatic Non-Small Cell Lung Cancer

Condition: Lung Cancer, Non-Small Cell  ·  Sponsor: GlaxoSmithKline

PhasePhase 3
Planned participants666
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

Sponsor, CRO or site team? See where this study is running → — listed sites, countries and recruiting context. Everything below is written for patients and caregivers.

About this study

This is a multicenter, randomized, double-blind, placebo-controlled study of niraparib plus pembrolizumab versus placebo plus pembrolizumab as maintenance therapy in participants with advanced or metastatic non-small cell lung cancer (NSCLC) who have achieved stable disease (SD), partial response (PR), or complete response (CR) following completion of standard of care first-line (SoC 1L) platinum-based induction chemotherapy with pembrolizumab. The primary hypotheses are: participants with confirmed diagnosis of NSCLC could benefit from niraparib plus pembrolizumab versus placebo plus pembrolizumab with respect to Progression-free survival (PFS) and Overall survival (OS).

This description comes directly from the study's public registry record.

Talk to the study team

No contact information is available for this study as per the public registry record.

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Locations (188)

GSK Investigational SiteFullerton, California, United States
GSK Investigational SiteLos Angeles, California, United States
GSK Investigational SiteLone Tree, Colorado, United States
GSK Investigational SiteNorwich, Connecticut, United States
GSK Investigational SiteTallahassee, Florida, United States
GSK Investigational SiteAtlanta, Georgia, United States
GSK Investigational SiteNewnan, Georgia, United States
GSK Investigational SiteNiles, Illinois, United States
GSK Investigational SiteIowa City, Iowa, United States
GSK Investigational SiteWorcester, Massachusetts, United States
GSK Investigational SiteMineola, New York, United States
GSK Investigational SiteNew York, New York, United States

+ 176 more locations — full list on the registry record.

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