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Study identifier: NCT04099290 Synced from ClinicalTrials.gov · August 07, 2026
● Study status: Recruiting

Circulating Tumor DNA (ctDNA) in Locally Advanced Head and Neck Squamous Cell Carcinoma

Condition: Head and Neck Neoplasm · Carcinoma, Squamous Cell  ·  Sponsor: UNC Lineberger Comprehensive Cancer Center

PhaseN/A
Planned participants50
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

Circulating tumor DNA (ctDNA) is a blood-based test that measures dying or dead cancer cells that are already circulating in the blood. In this study, the investigators will enroll patients who are planning to receive surgery to remove their head and neck cancer. The investigators are interested to learn how ctDNA levels change with surgery and over the course of time. The investigators also want to determine if there are certain features of the tumor or the patient themselves that might cause ctDNA to be higher than other patients. Also, the investigators want to explore if the detection of ctDNA following surgery is related to cancer recurrence.

This description comes directly from the study's public registry record.

Talk to the study team

Siddharth Sheth, MD  ·  (919) 966-3856  ·  Siddharth.Sheth@unchealth.unc.edu

Rebecca Green, MSW  ·  (984) 974-8440  ·  rlgreen@med.unc.edu

Always discuss trial participation with your own doctor first.

Locations (1)

University of North Carolina at Chapel HillChapel Hill, North Carolina, United StatesRecruiting

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