EICHORCondition: B Acute Lymphoblastic Leukemia · B Lymphoblastic Lymphoma · Down Syndrome · Sponsor: National Cancer Institute (NCI)
This phase III trial studies how well blinatumomab works in combination with chemotherapy in treating patients with newly diagnosed, standard risk B-lymphoblastic leukemia or B-lymphoblastic lymphoma with or without Down syndrome. Monoclonal antibodies, such as blinatumomab, may induce changes in the body's immune system and may interfere with the ability of cancer cells to grow and spread. Chemotherapy drugs, such as vincristine, dexamethasone, prednisone, prednisolone, pegaspargase, methotrexate, cytarabine, mercaptopurine, doxorubicin, cyclophosphamide, and thioguanine, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Leucovorin decreases the toxic effects of methotrexate. Giving monoclonal antibody therapy with chemotherapy may kill more cancer cells. Giving blinatumomab and combination chemotherapy may work better than combination chemotherapy alone in treating patients with B-ALL. This trial also assigns patients into different chemotherapy treatment regimens based on risk (the chance of cancer returning after treatment). Treating patients with chemotherapy based on risk may help doctors decide which patients can best benefit from which chemotherapy treatment regimens.
This description comes directly from the study's public registry record.
No contact information is available for this study as per the public registry record.
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| Children's Hospital of Alabama | Birmingham, Alabama, United States | — |
| USA Health Strada Patient Care Center | Mobile, Alabama, United States | — |
| Providence Alaska Medical Center | Anchorage, Alaska, United States | — |
| Banner Children's at Desert | Mesa, Arizona, United States | — |
| Phoenix Childrens Hospital | Phoenix, Arizona, United States | — |
| Banner University Medical Center - Tucson | Tucson, Arizona, United States | — |
| Arkansas Children's Hospital | Little Rock, Arkansas, United States | — |
| Kaiser Permanente Downey Medical Center | Downey, California, United States | — |
| City of Hope Comprehensive Cancer Center | Duarte, California, United States | — |
| Loma Linda University Medical Center | Loma Linda, California, United States | — |
| Miller Children's and Women's Hospital Long Beach | Long Beach, California, United States | — |
| Children's Hospital Los Angeles | Los Angeles, California, United States | — |
+ 216 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT03914625