EICHORCondition: Pancreatic Cancer · Metastatic Pancreatic Cancer · Metastatic Pancreatic Adenocarcinoma · Sponsor: Astellas Pharma Global Development, Inc.
Zolbetuximab is being studied as a treatment for people with pancreatic cancer. Most people with pancreatic cancer have a protein called Claudin 18.2 (CLDN18.2) in their tumor. Zolbetuximab is thought to work by attaching to CLDN 18.2 in their tumor. This switches on the body's immune system to attack the tumor. Zolbetuximab is a potential treatment for people with pancreatic cancer. There is an unmet medical need to treat people with pancreatic cancer. This study will help find the dose of zolbetuximab to be used with chemotherapy and provide more information on this treatment in adults with metastatic pancreatic cancer. The study is currently ongoing globally. People in this study will be treated with either zolbetuximab and chemotherapy or chemotherapy by itself. The study's main aims are to find a suitable dose of zolbetuximab to be used with chemotherapy in the second part of this study, to check if zolbetuximab and chemotherapy compared to chemotherapy by itself can improve the survival of people with pancreatic cancer, and to check the safety of zolbetuximab when given with chemotherapy and how well people cope with medical problems during the study. Adults with metastatic pancreatic cancer can take part. Their cancer is metastatic, has the CLDN18.2 marker in a tumor sample and has not previously been treated with chemotherapy. Metastatic means the cancer has spread to other parts of the body. People cannot take part are if they have recently had radiotherapy and ha…
This description comes directly from the study's public registry record.
No contact information is available for this study as per the public registry record.
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| St. Joseph Heritage Medical Group | Fullerton, California, United States | — |
| TOI Clinical research | Whittier, California, United States | — |
| Midstate Medical Center | Meriden, Connecticut, United States | — |
| Lynn Cancer Institute | Boca Raton, Florida, United States | — |
| Baptist Health | Miami, Florida, United States | — |
| Cancer Treatment Centers of Atlanta | Newnan, Georgia, United States | — |
| University of Illinois at Chicago | Chicago, Illinois, United States | — |
| Norton Cancer Institute (NCI) | Louisville, Kentucky, United States | — |
| Ochsner Health System | New Orleans, Louisiana, United States | — |
| David C Pratt Cancer Center | Creve Coeur, Missouri, United States | — |
| Memorial Sloan Kettering Basking Ridge | Basking Ridge, New Jersey, United States | — |
| Memorial Sloan Kettering Bergen | Montvale, New Jersey, United States | — |
+ 124 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT03816163