EICHORCondition: Bleeding Post-mechanical Valve Replacement · Thromboembolism Post-mechanical Valve Replacement · Sponsor: Population Health Research Institute
Interested? Contact the study team ↓
This study evaluates the use of a lower INR target (1.5 to 2.5) in patients with a mechanical bileaflet heart valve in the aortic position. This study will inform physicians about whether a lower INR target will decrease the risk of bleeding or increase the risk of blood clot formation and stroke. These results have the potential to reduce the burden of bleeding in patients with a mechanical heart valve who require lifelong warfarin (Coumadin) treatment.
This description comes directly from the study's public registry record.
Emilie Belley-Côté, MD, MSc · 905-527-4322 · emilie.belley-cote@phri.ca
Richard Whitlock, MD, PhD · 905-527-4322 · richard.whitlock@phri.ca
There is no obligation to join — the study team can answer your questions about taking part.
Always discuss trial participation with your own doctor first.
Inclusion criteria: * Age is 18 or older at the time of enrolment * Have had a bileaflet mechanical heart valve implant in the aortic position 3 or more months ago * Written informed consent from either the patient or substitute decision maker Exclusion criteria: * Has a second implanted mechanical valve (any position) * Lower boundary of planned INR range is less than 2.0 * Pregnant or expecting to become pregnant during the study follow-up
Reproduced word-for-word from the public registry record — the study team can answer questions about it.
| Ziekenhuis Oost-Limburg | Genk, Limburg, Belgium | Recruiting |
| AZ Oostende | Ostend, West-Vlaanderen, Belgium | Recruiting |
| Imelda Hospital | Keerbergen, Belgium | Recruiting |
| Universitair Ziekenhuis Leuven | Leuven, Belgium | Recruiting |
| University of Botswana, at Princess Marina Hospital | Gaborone, Botswana | Recruiting |
| Sociedade Hospitalar Angelina Caron | Campina Grande do Sul, Paraná, Brazil | Recruiting |
| HEW Cardiologia LTDA | Joinville, Santa Catarina, Brazil | Recruiting |
| InCor-HCFMUSP | Cerqueira César, São Paulo, Brazil | Recruiting |
| Fundação Universitária de Cardiologia mantededora do Instituto de Cardiologia e Transplantes do Distrito Federal | Brasília, Brazil | Recruiting |
| Dante Pazzanese Institute of Cardiology | São Paulo, Brazil | Recruiting |
| St. Elizabeth Catholic General Hospital | Kumbo, Cameroon | Recruiting |
| Nova Scotia Health Authority | Halifax, Nova Scotia, Canada | Not Yet Recruiting |
+ 23 more locations — full list on the registry record.
This study lists sites in the areas below. Each link shows other recruiting studies near that city, from the public registry record.
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Source record: clinicaltrials.gov/study/NCT03636295