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Study identifier: NCT03504644 Synced from ClinicalTrials.gov · August 07, 2026
● Study status: Active Not Recruiting

Venetoclax and Vincristine in Treating Patients With Relapsed or Refractory T-cell or B-cell Acute Lymphoblastic Leukemia

Condition: Recurrent Adult Lymphoblastic Lymphoma · Recurrent B Acute Lymphoblastic Leukemia · Recurrent B Lymphoblastic Lymphoma  ·  Sponsor: ECOG-ACRIN Cancer Research Group

PhasePhase 1/Phase 2
Planned participants40
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

Sponsor, CRO or site team? See where this study is running → — listed sites, countries and recruiting context. Everything below is written for patients and caregivers.

About this study

This phase Ib/II trial studies the side effects and best dose of venetoclax and how well it works when given together with vincristine in treating patients with T-cell or B-cell acute lymphoblastic leukemia that has come back (recurrent) or does not respond to treatment (refractory). Venetoclax may stop the growth of cancer cells by blocking Bcl-2, a protein needed for cancer cell survival. Chemotherapy drugs, such as vincristine, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving venetoclax together with vincristine may work better in treating patients with acute lymphoblastic leukemia compared to vincristine alone.

This description comes directly from the study's public registry record.

Talk to the study team

No contact information is available for this study as per the public registry record.

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Locations (170)

Anchorage Associates in Radiation MedicineAnchorage, Alaska, United States
Anchorage Radiation Therapy CenterAnchorage, Alaska, United States
Alaska Breast Care and Surgery LLCAnchorage, Alaska, United States
Alaska Oncology and Hematology LLCAnchorage, Alaska, United States
Alaska Women's Cancer CareAnchorage, Alaska, United States
Anchorage Oncology CentreAnchorage, Alaska, United States
Katmai Oncology GroupAnchorage, Alaska, United States
Providence Alaska Medical CenterAnchorage, Alaska, United States
Mayo Clinic Hospital in ArizonaPhoenix, Arizona, United States
Mayo Clinic in ArizonaScottsdale, Arizona, United States
Mercy Hospital Fort SmithFort Smith, Arkansas, United States
CARTI Cancer CenterLittle Rock, Arkansas, United States

+ 158 more locations — full list on the registry record.

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