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Study identifier: NCT03377491 Synced from ClinicalTrials.gov · August 06, 2026
● Study status: Completed

Effect of Tumor Treating Fields (TTFields, 150 kHz) as Front-Line Treatment of Locally-advanced Pancreatic Adenocarcinoma Concomitant With Gemcitabine and Nab-paclitaxel (PANOVA-3)

Condition: Pancreas Adenocarcinoma  ·  Sponsor: NovoCure Ltd.

PhasePhase 3
Planned participants571
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

Brief Summary: The study is a prospective, randomized controlled phase III trial aimed to test the efficacy and safety of Tumor Treating Fields (TTFields) in combination with gemcitabine and nab-paclitaxel, for front line treatment of locally-advanced pancreatic adenocarcinoma.The device is an experimental, portable, battery operated device for chronic administration of alternating electric fields (termed TTFields or TTF) to the region of the malignant tumor, by means of surface, insulated electrode arrays.

This description comes directly from the study's public registry record.

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Locations (199)

Grandview Medical Center, Cancer CenterBirmingham, Alabama, United States
Infirmary Cancer CareMobile, Alabama, United States
Banner MD Anderson Cancer CenterGilbert, Arizona, United States
Arizona Oncology Associates, PC- HOPE - US Oncology ResearchTucson, Arizona, United States
University of Arizona Cancer CenterTucson, Arizona, United States
Pacific Cancer Medical CenterAnaheim, California, United States
Providence Medical FoundationFullerton, California, United States
Cedars-Sinai Medical CenterLos Angeles, California, United States
Dignity Health - Mercy Cancer CentersSacramento, California, United States
Sutter Cancer Center SacramentoSacramento, California, United States
Ridley-Tree Cancer CenterSanta Barbara, California, United States
Adventist Health St. Helena - Martin-O'Neil Cancer Center (MOCC)St. Helena, California, United States

+ 187 more locations — full list on the registry record.

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