EICHORCondition: Cancer of Ovary · Cancer of the Ovary · Neoplasms, Ovarian · Sponsor: Roswell Park Cancer Institute
This study will evaluate the immunologic and potential clinical effectiveness of intensive locoregional sequential intraperitoneal (IP) cisplatin (IPC) with intravenous (iv) paclitaxel followed by peritoneal infusion of a chemokine modulatory (CKM) regimen composed of a cocktail of IP rintatolimod and interferon-alpha (IFNα) for patients with advanced stage ovarian cancer (III-IV) at primary neoadjuvant setting. In the safety phase I phase, we determined the tolerable dose of IPC-CKM. In this phase 2 we will add intradermal (ID) autologous αDC1 vaccines (known to be nontoxic) to the tolerable IPC-CKM regimen. The effectiveness will be determined by rate of complete pathologic response.
This description comes directly from the study's public registry record.
No contact information is available for this study as per the public registry record.
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| UPMC CancerCenter at Magee-Womens Hospital of UPMC | Pittsburgh, Pennsylvania, United States | — |
| Hillman Cancer Center | Pittsburgh, Pennsylvania, United States | — |
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Source record: clinicaltrials.gov/study/NCT02432378